FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029220859> ?p ?o ?g. }

• W2029220859 endingPage "443" @default.
• W2029220859 startingPage "437" @default.
• W2029220859 abstract "Phosphatidic acid phosphohydrolase-1 (PAP-1) activity is reversibly inhibited by fatty acids and their acyl-CoA esters and it appears paradoxical that these effectors have been reported to increase the liver’s esterification capacity by translocating the rate-limiting enzyme PAP-1 from cytosol to the endoplasmic reticulum. Therefore, we have examined the effect of oleate, oleoyl-CoA, and spermine on the activation and translocation of PAP-1 of rat liver. PAP-1 activity is directly inhibited by oleic acid and oleoyl-CoA ester in an allosteric manner, resulting in the formation of inactive PAP-1-fatty acid (or -acyl-CoA) complex, even in the absence of any subcellular structures. Such association/aggregation of PAP-1 can be easily collected by centrifugation and may explain the apparent translocation phenomenon of this enzyme to a particular structure in the presence of fatty acids or acyl-CoA esters as reported in many works. Indeed, incubation of cytosol fraction alone with oleate or oleoyl-CoA at 37 °C, followed by centrifugation, induces a significant increase (sevenfold) in PAP-1 activity in the pellet fraction. This displacement is accompanied by an increase in the specific activity of PAP-1 in the pellet fraction. Spermine is less effective than oleate in inducing the displacement of PAP-1 activity from cytosol to the pellet fraction in the absence of any membrane structures. This apparent translocation of PAP-1 is also promoted when homogenate fraction was incubated with oleate prior to the preparation of cytosol and microsomal fraction. Thus, many of the announced factors, including fatty acids, would promote the in vitro association/aggregation of PAP-1 enzyme rather than its translocation, and therefore, re-evaluation of the reported effects on PAP-1 translocation phenomenon is required. It is proposed that fatty acids and their esters would favour β-oxidation over esterification by promoting the forming of inactive associated PAP-1 in situations such as starvation and metabolic stress in which there is an increased supply of fatty acids to the liver." @default.
• W2029220859 created "2016-06-24" @default.
• W2029220859 creator A5008669450 @default.
• W2029220859 creator A5016993858 @default.
• W2029220859 creator A5065228417 @default.
• W2029220859 creator A5071178350 @default.
• W2029220859 creator A5075969440 @default.
• W2029220859 date "2005-05-01" @default.
• W2029220859 modified "2023-10-05" @default.
• W2029220859 title "Relationship between the inhibition of phosphatidic acid phosphohydrolase-1 by oleate and oleoyl-CoA ester and its apparent translocation" @default.
• W2029220859 cites W1504466755 @default.
• W2029220859 cites W1526269925 @default.
• W2029220859 cites W1565640556 @default.
• W2029220859 cites W1602344919 @default.
• W2029220859 cites W1673932087 @default.
• W2029220859 cites W1763805809 @default.
• W2029220859 cites W1764076074 @default.
• W2029220859 cites W1796129911 @default.
• W2029220859 cites W1860656716 @default.
• W2029220859 cites W1890458784 @default.
• W2029220859 cites W1968956158 @default.
• W2029220859 cites W1971476654 @default.
• W2029220859 cites W1975019729 @default.
• W2029220859 cites W1975238532 @default.
• W2029220859 cites W1978360221 @default.
• W2029220859 cites W1990805315 @default.
• W2029220859 cites W1996181331 @default.
• W2029220859 cites W2006101699 @default.
• W2029220859 cites W2018677253 @default.
• W2029220859 cites W2025091409 @default.
• W2029220859 cites W2035450414 @default.
• W2029220859 cites W2039543531 @default.
• W2029220859 cites W2048323210 @default.
• W2029220859 cites W2052176738 @default.
• W2029220859 cites W2057680304 @default.
• W2029220859 cites W2058308749 @default.
• W2029220859 cites W2059416045 @default.
• W2029220859 cites W2060492964 @default.
• W2029220859 cites W2062203427 @default.
• W2029220859 cites W2062487777 @default.
• W2029220859 cites W2075263919 @default.
• W2029220859 cites W2075445719 @default.
• W2029220859 cites W2082442597 @default.
• W2029220859 cites W2090550715 @default.
• W2029220859 cites W2093297927 @default.
• W2029220859 cites W2124937824 @default.
• W2029220859 cites W2160241210 @default.
• W2029220859 cites W2164477432 @default.
• W2029220859 cites W2167351040 @default.
• W2029220859 cites W2186479551 @default.
• W2029220859 cites W2399198258 @default.
• W2029220859 cites W2400687908 @default.
• W2029220859 cites W296318936 @default.
• W2029220859 cites W305526619 @default.
• W2029220859 doi "https://doi.org/10.1016/j.biochi.2005.01.003" @default.
• W2029220859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15820750" @default.
• W2029220859 hasPublicationYear "2005" @default.
• W2029220859 type Work @default.
• W2029220859 sameAs 2029220859 @default.
• W2029220859 citedByCount "17" @default.
• W2029220859 countsByYear W20292208592012 @default.
• W2029220859 countsByYear W20292208592013 @default.
• W2029220859 countsByYear W20292208592014 @default.
• W2029220859 countsByYear W20292208592021 @default.
• W2029220859 crossrefType "journal-article" @default.
• W2029220859 hasAuthorship W2029220859A5008669450 @default.
• W2029220859 hasAuthorship W2029220859A5016993858 @default.
• W2029220859 hasAuthorship W2029220859A5065228417 @default.
• W2029220859 hasAuthorship W2029220859A5071178350 @default.
• W2029220859 hasAuthorship W2029220859A5075969440 @default.
• W2029220859 hasConcept C158617107 @default.
• W2029220859 hasConcept C181199279 @default.
• W2029220859 hasConcept C185592680 @default.
• W2029220859 hasConcept C2776109719 @default.
• W2029220859 hasConcept C2776909261 @default.
• W2029220859 hasConcept C2778918659 @default.
• W2029220859 hasConcept C2781403372 @default.
• W2029220859 hasConcept C41625074 @default.
• W2029220859 hasConcept C543025807 @default.
• W2029220859 hasConcept C55493867 @default.
• W2029220859 hasConcept C7623868 @default.
• W2029220859 hasConcept C86803240 @default.
• W2029220859 hasConcept C87644729 @default.
• W2029220859 hasConcept C98539663 @default.
• W2029220859 hasConceptScore W2029220859C158617107 @default.
• W2029220859 hasConceptScore W2029220859C181199279 @default.
• W2029220859 hasConceptScore W2029220859C185592680 @default.
• W2029220859 hasConceptScore W2029220859C2776109719 @default.
• W2029220859 hasConceptScore W2029220859C2776909261 @default.
• W2029220859 hasConceptScore W2029220859C2778918659 @default.
• W2029220859 hasConceptScore W2029220859C2781403372 @default.
• W2029220859 hasConceptScore W2029220859C41625074 @default.
• W2029220859 hasConceptScore W2029220859C543025807 @default.
• W2029220859 hasConceptScore W2029220859C55493867 @default.
• W2029220859 hasConceptScore W2029220859C7623868 @default.
• W2029220859 hasConceptScore W2029220859C86803240 @default.
• W2029220859 hasConceptScore W2029220859C87644729 @default.
• W2029220859 hasConceptScore W2029220859C98539663 @default.

• next