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- W2029221569 abstract "Subclinical hypothyroidism is a laboratory definition: a raised concentration of thyroid stimulating hormone (TSH) yet a normal concentration of free thyroid hormone, without specific symptoms of thyroid dysfunction. Patients with subclinical hypothyroidism have an increased risk of progressing to overt hypothyroidism. Yet uncertainty exists as to the benefits of treating such patients.Recent systematic reviews of cohort studies have shown a significant increase in coronary heart disease and cardiovascular related mortality in people with subclinical hypothyroidism and a TSH concentration >10 mU/l, but no difference in overall mortality.1 2 The benefits of treating subclinical hypothyroidism are also uncertain: although two systematic reviews have suggested that treatment may decrease total cholesterol and low density lipoprotein cholesterol levels, particularly in people with TSH concentrations of >10 mU/l,3 4 no research has shown a decrease in coronary heart disease or mortality with treatment.The Clinical Evidence review reports mixed results from small …" @default.
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- W2029221569 date "2008-07-16" @default.
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- W2029221569 title "Should we treat subclinical hypothyroidism?" @default.
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- W2029221569 doi "https://doi.org/10.1136/bmj.a834" @default.
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