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• W2029229070 endingPage "852" @default.
• W2029229070 startingPage "835" @default.
• W2029229070 abstract "Better understanding of the molecular biology of renal cell carcinoma (RCC) has led to the development of several targeted anti-cancer agents, several of which have since received approval for treatment of advanced disease. Two of these, the intravenous agent temsirolimus and the oral everolimus, exhibit antitumor effects through inhibition of the mammalian target of rapamycin (mTOR) pathway. This article reviews their mechanisms of action in the context of the current understanding of RCC pathophysiology, the clinical data leading to their approval, class-specific toxicities, potential molecular mechanisms behind treatment resistance and novel treatment approaches for RCC that incorporate mTOR blockade." @default.
• W2029229070 created "2016-06-24" @default.
• W2029229070 creator A5009190675 @default.
• W2029229070 creator A5059063118 @default.
• W2029229070 creator A5091859782 @default.
• W2029229070 date "2011-08-01" @default.
• W2029229070 modified "2023-10-17" @default.
• W2029229070 title "mTOR Inhibitors in Advanced Renal Cell Carcinoma" @default.
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