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- W2029231788 abstract "Amlodipine (AML), which belongs to the 1,4-dihydropyridine calcium channel antagonists, possesses pharmacological and pharmacokinetic profile that distinguishes it from other agents of this class. Pentylenetetrazole (PTZ)-induced clonic and tonic convulsions in mice were significantly reduced by administration of AML at 10 mg/kg. At this dose AML remained without influence upon the plasma level of PTZ. The ED50 value of AML against clonic seizures induced by PTZ was 5.4 mg/kg. This calcium channel antagonist (at 2.5 mg/kg) combined with ethosuximide (ETX), valproate magnesium (VPA) or phenobarbital (PB) significantly reduced their ED50 values against clonic phase of PTZ-induced seizures. AML administered alone or in combination with antiepileptic drugs (AEDs) worsened the motor performance of mice in the chimney test. However, these treatments remained without significant influence on the retention time in the passive avoidance test. Plasma levels of antiepileptics remained unchanged in the presence of AML. The results indicate that AML does not seem a good candidate for a combination therapy in epileptic patients because of its adverse potential." @default.
- W2029231788 created "2016-06-24" @default.
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- W2029231788 date "2001-04-01" @default.
- W2029231788 modified "2023-10-11" @default.
- W2029231788 title "Amlodipine enhances the activity of antiepileptic drugs against pentylenetetrazole-induced seizures" @default.
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- W2029231788 cites W1823876933 @default.
- W2029231788 cites W1963750397 @default.
- W2029231788 cites W1964692105 @default.
- W2029231788 cites W1964809668 @default.
- W2029231788 cites W1966837740 @default.
- W2029231788 cites W1967827292 @default.
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- W2029231788 cites W1973500003 @default.
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- W2029231788 cites W1982221637 @default.
- W2029231788 cites W1985697613 @default.
- W2029231788 cites W1986868702 @default.
- W2029231788 cites W1987721729 @default.
- W2029231788 cites W1988074297 @default.
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- W2029231788 doi "https://doi.org/10.1016/s0091-3057(01)00468-3" @default.
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