FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029238181> ?p ?o ?g. }

• W2029238181 endingPage "1530" @default.
• W2029238181 startingPage "1521" @default.
• W2029238181 abstract "BACKGROUND:Increased arterial stiffness as measured by aortic pulse wave velocity (aPWV) predicts cardiovascular events and mortality and is elevated in patients with COPD. Prior investigation suggests that a long-acting β-agonist (LABA)/inhaled corticosteroid (ICS) lowers aPWV in patients with baseline aPWV ≥ 11 m/s. This study compared the effect of the ICS/LABA fluticasone furoate/vilanterol (FF/VI), 100/25 μg, delivered via the ELLIPTA dry powder inhaler, with tiotropium bromide (TIO), 18 μg, on aPWV.METHODS:This multicenter, randomized, blinded, double-dummy, parallel-group, 12-week study compared FF/VI and TIO, both administered once daily. The primary end point was aPWV change from baseline at 12 weeks. Safety end points included adverse events (AEs), vital signs, and clinical laboratory tests.RESULTS:Two hundred fifty-seven patients with COPD and aPWV ≥ 11 m/s were randomized; 87% had prior cardiovascular events and/or risk. The mean difference in aPWV between FF/VI and TIO at week 12 was not significant (P= .484). Because the study did not contain a placebo arm, a post hoc analysis was performed to show that both treatments lowered aPWV by an approximate difference of 1 m/s compared with baseline. The proportion of patients reporting AEs was similar with FF/VI (24%) and TIO (18%). There were no changes in clinical concern for vital signs or clinical laboratory tests.CONCLUSIONS:No differences on aPWV were observed between FF/VI and TIO. However, further studies with a placebo arm are required to establish definitively whether long-acting bronchodilators lower aPWV. Both treatments demonstrated an acceptable tolerability profile.TRIAL REGISTRY:ClinicalTrials.gov; No.: NCT01395888; URL:www.clinicaltrials.gov." @default.
• W2029238181 created "2016-06-24" @default.
• W2029238181 creator A5031226144 @default.
• W2029238181 creator A5048658342 @default.
• W2029238181 creator A5052214507 @default.
• W2029238181 creator A5061197238 @default.
• W2029238181 creator A5065946882 @default.
• W2029238181 creator A5074717800 @default.
• W2029238181 date "2014-12-01" @default.
• W2029238181 modified "2023-09-25" @default.
• W2029238181 title "Long-Acting Bronchodilators and Arterial Stiffness in Patients With COPD" @default.
• W2029238181 cites W1814339923 @default.
• W2029238181 cites W1980816104 @default.
• W2029238181 cites W1984680175 @default.
• W2029238181 cites W1987138414 @default.
• W2029238181 cites W1989555228 @default.
• W2029238181 cites W2011364685 @default.
• W2029238181 cites W2049759474 @default.
• W2029238181 cites W2050366198 @default.
• W2029238181 cites W2063830101 @default.
• W2029238181 cites W2070681150 @default.
• W2029238181 cites W2076383107 @default.
• W2029238181 cites W2078800845 @default.
• W2029238181 cites W2082097252 @default.
• W2029238181 cites W2100738224 @default.
• W2029238181 cites W2102015915 @default.
• W2029238181 cites W2109608278 @default.
• W2029238181 cites W2109761314 @default.
• W2029238181 cites W2110552101 @default.
• W2029238181 cites W2110635468 @default.
• W2029238181 cites W2111811929 @default.
• W2029238181 cites W2115430937 @default.
• W2029238181 cites W2116301251 @default.
• W2029238181 cites W2135293413 @default.
• W2029238181 cites W2136131355 @default.
• W2029238181 cites W2138209376 @default.
• W2029238181 cites W2139503178 @default.
• W2029238181 cites W2141559845 @default.
• W2029238181 cites W2143691602 @default.
• W2029238181 cites W2143695552 @default.
• W2029238181 cites W2148101681 @default.
• W2029238181 cites W2155427136 @default.
• W2029238181 cites W2162627911 @default.
• W2029238181 cites W2165328782 @default.
• W2029238181 cites W2165340553 @default.
• W2029238181 cites W2166386062 @default.
• W2029238181 cites W2740155436 @default.
• W2029238181 cites W3149179143 @default.
• W2029238181 doi "https://doi.org/10.1378/chest.13-2859" @default.
• W2029238181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25058845" @default.
• W2029238181 hasPublicationYear "2014" @default.
• W2029238181 type Work @default.
• W2029238181 sameAs 2029238181 @default.
• W2029238181 citedByCount "26" @default.
• W2029238181 countsByYear W20292381812015 @default.
• W2029238181 countsByYear W20292381812016 @default.
• W2029238181 countsByYear W20292381812017 @default.
• W2029238181 countsByYear W20292381812018 @default.
• W2029238181 countsByYear W20292381812019 @default.
• W2029238181 countsByYear W20292381812020 @default.
• W2029238181 countsByYear W20292381812021 @default.
• W2029238181 countsByYear W20292381812023 @default.
• W2029238181 crossrefType "journal-article" @default.
• W2029238181 hasAuthorship W2029238181A5031226144 @default.
• W2029238181 hasAuthorship W2029238181A5048658342 @default.
• W2029238181 hasAuthorship W2029238181A5052214507 @default.
• W2029238181 hasAuthorship W2029238181A5061197238 @default.
• W2029238181 hasAuthorship W2029238181A5065946882 @default.
• W2029238181 hasAuthorship W2029238181A5074717800 @default.
• W2029238181 hasBestOaLocation W20292381811 @default.
• W2029238181 hasConcept C126322002 @default.
• W2029238181 hasConcept C142724271 @default.
• W2029238181 hasConcept C164705383 @default.
• W2029238181 hasConcept C197934379 @default.
• W2029238181 hasConcept C204787440 @default.
• W2029238181 hasConcept C27081682 @default.
• W2029238181 hasConcept C2775850156 @default.
• W2029238181 hasConcept C2776042228 @default.
• W2029238181 hasConcept C2776780178 @default.
• W2029238181 hasConcept C2776804153 @default.
• W2029238181 hasConcept C2777419714 @default.
• W2029238181 hasConcept C2778319312 @default.
• W2029238181 hasConcept C2779028295 @default.
• W2029238181 hasConcept C2780261241 @default.
• W2029238181 hasConcept C67761136 @default.
• W2029238181 hasConcept C71924100 @default.
• W2029238181 hasConcept C84393581 @default.
• W2029238181 hasConceptScore W2029238181C126322002 @default.
• W2029238181 hasConceptScore W2029238181C142724271 @default.
• W2029238181 hasConceptScore W2029238181C164705383 @default.
• W2029238181 hasConceptScore W2029238181C197934379 @default.
• W2029238181 hasConceptScore W2029238181C204787440 @default.
• W2029238181 hasConceptScore W2029238181C27081682 @default.
• W2029238181 hasConceptScore W2029238181C2775850156 @default.
• W2029238181 hasConceptScore W2029238181C2776042228 @default.
• W2029238181 hasConceptScore W2029238181C2776780178 @default.
• W2029238181 hasConceptScore W2029238181C2776804153 @default.
• W2029238181 hasConceptScore W2029238181C2777419714 @default.

• next