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- W2029239227 abstract "Epigenetic modifications are a central mechanism for regulating chromatin structure and gene expression in the brain. A wide array of histone- and DNA-modifying enzymes have been identified as critical regulators of neuronal function, memory formation, and as causative agents in neurodevelopmental and neuropsychiatric disorders. Chromatin modifying enzymes are frequently incorporated into large multi-protein co-activator and co-repressor complexes, where the activity of multiple enzymes is both spatially and temporally coordinated. In this review, we discuss negative regulation of gene expression by co-repressor complexes, and the role of co-repressors and their binding partners in neuronal function, memory, and disease. This article is part of the Special Issue entitled ‘Neuroepigenetic Disorders’." @default.
- W2029239227 created "2016-06-24" @default.
- W2029239227 creator A5004002028 @default.
- W2029239227 creator A5017550855 @default.
- W2029239227 date "2014-05-01" @default.
- W2029239227 modified "2023-09-23" @default.
- W2029239227 title "Transcriptional co-repressors and memory storage" @default.
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- W2029239227 doi "https://doi.org/10.1016/j.neuropharm.2014.01.003" @default.
- W2029239227 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4029340" @default.
- W2029239227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24440532" @default.
- W2029239227 hasPublicationYear "2014" @default.
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