FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029246369> ?p ?o ?g. }

• W2029246369 endingPage "260" @default.
• W2029246369 startingPage "253" @default.
• W2029246369 abstract "Alveolar formation or alveolarization is orchestrated by a finely regulated and complex interaction between growth factors and extracellular matrix proteins. The lung parenchyma contains various extracellular matrix proteins including proteoglycans, which are composed of glycosaminoglycans (GAGs) linked to a protein core. Although GAGs are known to regulate growth factor distribution and activity according to their degree of sulfation the role of sulfated GAG in the respiratory system is not well understood. The degree of sulfation of GAGs is regulated in part, by sulfatases that remove sulfate groups. In vertebrates, the enzyme Sulfatase-Modifying Factor 1 (Sumf1) activates all sulfatases. Here we utilized mice lacking Sumf1−/− to study the importance of proteoglycan desulfation in lung development. The Sumf1−/− mice have normal lungs up until the onset of alveolarization at post-natal day 5 (P5). We detected increased deposition of sulfated GAG throughout the lung parenchyma and a decrease in alveolar septa formation. Moreover, stereological analysis showed that the alveolar volume is 20% larger in Sumf1−/− as compared to wild type (WT) mice at P10 and P30. Additionally, pulmonary function test was consistent with increased alveolar volume. Genetic experiments demonstrate that in Sumf1−/− mice arrest of alveolarization is independent of fibroblast growth factor signaling. In turn, the Sumf1−/− mice have increased transforming growth factor β (TGFβ) signaling and in vivo injection of TGFβ neutralizing antibody leads to normalization of alveolarization. Thus, absence of sulfatase activity increases sulfated GAG deposition in the lungs causing deregulation of TGFβ signaling and arrest of alveolarization." @default.
• W2029246369 created "2016-06-24" @default.
• W2029246369 creator A5020456157 @default.
• W2029246369 creator A5056795266 @default.
• W2029246369 creator A5069298459 @default.
• W2029246369 creator A5077487765 @default.
• W2029246369 date "2012-05-01" @default.
• W2029246369 modified "2023-09-27" @default.
• W2029246369 title "Sulfatases are determinants of alveolar formation" @default.
• W2029246369 cites W1840439659 @default.
• W2029246369 cites W1965144118 @default.
• W2029246369 cites W1966939472 @default.
• W2029246369 cites W1970114263 @default.
• W2029246369 cites W1987062992 @default.
• W2029246369 cites W1987792538 @default.
• W2029246369 cites W2002023072 @default.
• W2029246369 cites W2004087842 @default.
• W2029246369 cites W2004902531 @default.
• W2029246369 cites W2005500369 @default.
• W2029246369 cites W2009629707 @default.
• W2029246369 cites W2013322971 @default.
• W2029246369 cites W2017071197 @default.
• W2029246369 cites W2037753264 @default.
• W2029246369 cites W2047727235 @default.
• W2029246369 cites W2052714318 @default.
• W2029246369 cites W2053206569 @default.
• W2029246369 cites W2057287059 @default.
• W2029246369 cites W2075982355 @default.
• W2029246369 cites W2083921257 @default.
• W2029246369 cites W2095185490 @default.
• W2029246369 cites W2097977053 @default.
• W2029246369 cites W2098137904 @default.
• W2029246369 cites W2101469591 @default.
• W2029246369 cites W2102091298 @default.
• W2029246369 cites W2109471619 @default.
• W2029246369 cites W2115163495 @default.
• W2029246369 cites W2116441979 @default.
• W2029246369 cites W2117997757 @default.
• W2029246369 cites W2122588714 @default.
• W2029246369 cites W2126196465 @default.
• W2029246369 cites W2132883077 @default.
• W2029246369 cites W2137787283 @default.
• W2029246369 cites W2156561769 @default.
• W2029246369 cites W2171037554 @default.
• W2029246369 cites W2171135911 @default.
• W2029246369 cites W4238813159 @default.
• W2029246369 doi "https://doi.org/10.1016/j.matbio.2012.02.001" @default.
• W2029246369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3340524" @default.
• W2029246369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22366163" @default.
• W2029246369 hasPublicationYear "2012" @default.
• W2029246369 type Work @default.
• W2029246369 sameAs 2029246369 @default.
• W2029246369 citedByCount "10" @default.
• W2029246369 countsByYear W20292463692017 @default.
• W2029246369 countsByYear W20292463692018 @default.
• W2029246369 countsByYear W20292463692019 @default.
• W2029246369 countsByYear W20292463692021 @default.
• W2029246369 countsByYear W20292463692022 @default.
• W2029246369 countsByYear W20292463692023 @default.
• W2029246369 crossrefType "journal-article" @default.
• W2029246369 hasAuthorship W2029246369A5020456157 @default.
• W2029246369 hasAuthorship W2029246369A5056795266 @default.
• W2029246369 hasAuthorship W2029246369A5069298459 @default.
• W2029246369 hasAuthorship W2029246369A5077487765 @default.
• W2029246369 hasBestOaLocation W20292463692 @default.
• W2029246369 hasConcept C118131993 @default.
• W2029246369 hasConcept C126322002 @default.
• W2029246369 hasConcept C142724271 @default.
• W2029246369 hasConcept C153074725 @default.
• W2029246369 hasConcept C155138218 @default.
• W2029246369 hasConcept C181199279 @default.
• W2029246369 hasConcept C185592680 @default.
• W2029246369 hasConcept C189165786 @default.
• W2029246369 hasConcept C196822366 @default.
• W2029246369 hasConcept C203014093 @default.
• W2029246369 hasConcept C22731427 @default.
• W2029246369 hasConcept C2777714996 @default.
• W2029246369 hasConcept C2778041096 @default.
• W2029246369 hasConcept C2779335624 @default.
• W2029246369 hasConcept C2780871851 @default.
• W2029246369 hasConcept C55493867 @default.
• W2029246369 hasConcept C71924100 @default.
• W2029246369 hasConcept C86803240 @default.
• W2029246369 hasConcept C95444343 @default.
• W2029246369 hasConceptScore W2029246369C118131993 @default.
• W2029246369 hasConceptScore W2029246369C126322002 @default.
• W2029246369 hasConceptScore W2029246369C142724271 @default.
• W2029246369 hasConceptScore W2029246369C153074725 @default.
• W2029246369 hasConceptScore W2029246369C155138218 @default.
• W2029246369 hasConceptScore W2029246369C181199279 @default.
• W2029246369 hasConceptScore W2029246369C185592680 @default.
• W2029246369 hasConceptScore W2029246369C189165786 @default.
• W2029246369 hasConceptScore W2029246369C196822366 @default.
• W2029246369 hasConceptScore W2029246369C203014093 @default.
• W2029246369 hasConceptScore W2029246369C22731427 @default.
• W2029246369 hasConceptScore W2029246369C2777714996 @default.
• W2029246369 hasConceptScore W2029246369C2778041096 @default.
• W2029246369 hasConceptScore W2029246369C2779335624 @default.

• next