FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029248429> ?p ?o ?g. }

• W2029248429 endingPage "239" @default.
• W2029248429 startingPage "229" @default.
• W2029248429 abstract "To characterize in vivo the high-affinity CB1 cannabinoid receptor (CB1R) selective anandamide analog AM1346 [alkoxyacid amide of N-eicosa-tetraenylamine] using drug discrimination. Substitution tests involved Δ9-tetrahydrocannabinol (Δ9-THC) and R-(+)-methanandamide (mAEA), a metabolically stable analog of anandamide (AEA), as well as the CB1R antagonist/inverse agonist rimonabant; d-amphetamine and morphine were also examined to assess pharmacological specificity. Rats were initially trained to discriminate between i.p.-injected vehicle and 3 mg/kg AM1346 (group 3 mg/kg; t′ = 20 min); subsequently, the rats were retrained with 5.6 mg/kg AM1346 (group 5.6 mg/kg; t′ = 20 min). Dose-generalization curves of AM1346, Δ9-THC, and mAEA suggested the following order of potency: Δ9-THC > AM1346 > mAEA both for rats discriminating between 3 and 5.6 mg/kg AM1346 from vehicle. In group 3 mg/kg, challenge by 1 mg/kg rimonabant resulted in parallel shifts to the right of the dose-generalization curves for Δ9-THC and AM1346, suggesting surmountable antagonism. Surmountable antagonism was not demonstrated with rimonabant–mAEA combinations. A long duration of effect was indicated when 3 mg/kg AM1346 was examined after different time intervals following i.p. administration (group 3 mg/kg). The in vivo half-life was close to 5 h. Neither d-amphetamine nor morphine generalized in either of groups 3 mg/kg and 5.6 mg/kg, suggesting pharmacological specificity. Unlike mAEA, the surmountable antagonism between rimonabant and AM1346 showed that the structural features of AEA can be modified to produce novel ligands that reduce the dissociation between the discriminative stimulus and rate decreasing effects of CB1R agonists derived from an AEA template." @default.
• W2029248429 created "2016-06-24" @default.
• W2029248429 creator A5000510528 @default.
• W2029248429 creator A5000540926 @default.
• W2029248429 creator A5032447166 @default.
• W2029248429 creator A5082509436 @default.
• W2029248429 date "2008-06-03" @default.
• W2029248429 modified "2023-10-15" @default.
• W2029248429 title "Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog" @default.
• W2029248429 cites W100628994 @default.
• W2029248429 cites W1824285398 @default.
• W2029248429 cites W1969338731 @default.
• W2029248429 cites W1969878290 @default.
• W2029248429 cites W1976813870 @default.
• W2029248429 cites W1983343132 @default.
• W2029248429 cites W1984563050 @default.
• W2029248429 cites W1987400624 @default.
• W2029248429 cites W1997418340 @default.
• W2029248429 cites W2003574853 @default.
• W2029248429 cites W2010381297 @default.
• W2029248429 cites W2018157558 @default.
• W2029248429 cites W2023434928 @default.
• W2029248429 cites W2024356538 @default.
• W2029248429 cites W2026556661 @default.
• W2029248429 cites W2027858920 @default.
• W2029248429 cites W2039666288 @default.
• W2029248429 cites W2049389590 @default.
• W2029248429 cites W2059410203 @default.
• W2029248429 cites W2069780284 @default.
• W2029248429 cites W2072073105 @default.
• W2029248429 cites W2074668691 @default.
• W2029248429 cites W2080275290 @default.
• W2029248429 cites W2080830674 @default.
• W2029248429 cites W2084836373 @default.
• W2029248429 cites W2118383133 @default.
• W2029248429 cites W2119826244 @default.
• W2029248429 cites W2125058598 @default.
• W2029248429 cites W2130408611 @default.
• W2029248429 cites W2133842855 @default.
• W2029248429 cites W2135180673 @default.
• W2029248429 cites W2148957867 @default.
• W2029248429 cites W2149191383 @default.
• W2029248429 cites W2150704327 @default.
• W2029248429 cites W2168886172 @default.
• W2029248429 cites W2170775670 @default.
• W2029248429 cites W2326531994 @default.
• W2029248429 cites W2404903906 @default.
• W2029248429 cites W4230416560 @default.
• W2029248429 doi "https://doi.org/10.1007/s00213-008-1199-3" @default.
• W2029248429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3727224" @default.
• W2029248429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18521574" @default.
• W2029248429 hasPublicationYear "2008" @default.
• W2029248429 type Work @default.
• W2029248429 sameAs 2029248429 @default.
• W2029248429 citedByCount "13" @default.
• W2029248429 countsByYear W20292484292013 @default.
• W2029248429 countsByYear W20292484292014 @default.
• W2029248429 countsByYear W20292484292015 @default.
• W2029248429 countsByYear W20292484292016 @default.
• W2029248429 crossrefType "journal-article" @default.
• W2029248429 hasAuthorship W2029248429A5000510528 @default.
• W2029248429 hasAuthorship W2029248429A5000540926 @default.
• W2029248429 hasAuthorship W2029248429A5032447166 @default.
• W2029248429 hasAuthorship W2029248429A5082509436 @default.
• W2029248429 hasBestOaLocation W20292484291 @default.
• W2029248429 hasConcept C126322002 @default.
• W2029248429 hasConcept C134018914 @default.
• W2029248429 hasConcept C148001335 @default.
• W2029248429 hasConcept C150903083 @default.
• W2029248429 hasConcept C170493617 @default.
• W2029248429 hasConcept C185592680 @default.
• W2029248429 hasConcept C202751555 @default.
• W2029248429 hasConcept C207001950 @default.
• W2029248429 hasConcept C2776433454 @default.
• W2029248429 hasConcept C2776885963 @default.
• W2029248429 hasConcept C2777383412 @default.
• W2029248429 hasConcept C2778938600 @default.
• W2029248429 hasConcept C2779783865 @default.
• W2029248429 hasConcept C2780871563 @default.
• W2029248429 hasConcept C55493867 @default.
• W2029248429 hasConcept C57992300 @default.
• W2029248429 hasConcept C71924100 @default.
• W2029248429 hasConcept C86803240 @default.
• W2029248429 hasConcept C89951826 @default.
• W2029248429 hasConcept C98274493 @default.
• W2029248429 hasConceptScore W2029248429C126322002 @default.
• W2029248429 hasConceptScore W2029248429C134018914 @default.
• W2029248429 hasConceptScore W2029248429C148001335 @default.
• W2029248429 hasConceptScore W2029248429C150903083 @default.
• W2029248429 hasConceptScore W2029248429C170493617 @default.
• W2029248429 hasConceptScore W2029248429C185592680 @default.
• W2029248429 hasConceptScore W2029248429C202751555 @default.
• W2029248429 hasConceptScore W2029248429C207001950 @default.
• W2029248429 hasConceptScore W2029248429C2776433454 @default.
• W2029248429 hasConceptScore W2029248429C2776885963 @default.
• W2029248429 hasConceptScore W2029248429C2777383412 @default.
• W2029248429 hasConceptScore W2029248429C2778938600 @default.
• W2029248429 hasConceptScore W2029248429C2779783865 @default.

• next