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- W2029248538 abstract "The purpose of this experiment was to determine whether the testes of the juvenile male rhesus monkey, receiving an invariant intermittent iv infusion of GnRH, produce a specific FSH secretion-inhibiting hormone that exerts its action directly at the level of the pituitary gland. To this end, five male rhesus monkeys between 13-18 months of age were treated with a chronic intermittent iv infusion of GnRH (0.1 microgram/min for 3 min every 3 h) for 10 weeks to elicit an adult-like pattern in the episodic activity of the pituitary-Leydig cell axis. Animals were then bilaterally orchidectomized, and on the day of castration testosterone replacement with testosterone-containing Silastic capsules that maintained circulating levels of the steroid at approximately 6 ng/ml was initiated. Sequential blood samples were collected before castration and at 4-5, 11-13, and 18-19 days thereafter. Removal of the testes resulted in a marked and selective hypersecretion of FSH, a response very similar to that observed previously in hypothalamus-lesioned GnRH-treated adult males. This finding indicates that it will be possible to substitute the juvenile male for the much larger hypothalamus-lesioned adult in future studies requiring a hypophysiotropic clamp preparation. Such a modification of this experimental model will facilitate an examination of the effects on FSH secretion of passive immunization with inhibin antisera and of administering pure inhibin peptides." @default.
- W2029248538 created "2016-06-24" @default.
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- W2029248538 date "1989-07-01" @default.
- W2029248538 modified "2023-09-27" @default.
- W2029248538 title "Bilateral Orchidectomy and Concomitant Testosterone Replacement in the Juvenile Male Rhesus Monkey (Macaca mulatta) Receiving an Invariant Intravenous Gonadotropin-Releasing Hormone (GnRH) Infusion Results, as in the Hypothalamus Lesioned GnRH-driven Adult Male, in a Selective Hypersecretion of Follicle- Stimulating Hormone*" @default.
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- W2029248538 doi "https://doi.org/10.1210/endo-125-1-257" @default.
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