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- W2029251152 abstract "A fraction isolated from neurointermediate pituitary lobes of Squalus acanthias has many biological and chromatographic characteristics resembling those ofoxyocin and its analogs that contain neutral amino acids substituted for leucine in the side chain. The Squalus fraction was directly compared by several assay methods with synthetic oxytocin analogs, several of which were prepared for this purpose by solid-phase synthesis. Pharmacological criteria indicate that the fraction does not derive its biological properties from any single one of the following: oxytocin, isotocin ([4-serine, 8-isoleucine]-oxytocin), glumitocin ([4-serine, 8-glutamine]-oxytocin), mesotocin ([8-isoleucine]-oxytocin), [4-serine]-oxytocin, [8-glutamine]-oxytocin, [8-phenylalanine]-oxytocin, [8-valine]-oxytocin, [8-serine]-oxytocin, or [8-alanine]-oxytocin. Despite pharmacological similarity of the Squalus fraction to an 8-substituted neutral oxytocin analog it does not appear to be any one of those available for testing. The fraction may, however, contain one or more of these in an unresolved mixture." @default.
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- W2029251152 date "1970-08-01" @default.
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- W2029251152 title "A fraction resembling oxytocin from Squalus acanthias: Pharmacological comparisons with synthetic peptides" @default.
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- W2029251152 doi "https://doi.org/10.1016/0016-6480(70)90096-1" @default.
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