Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029253143> ?p ?o ?g. }
- W2029253143 endingPage "7428" @default.
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- W2029253143 abstract "PolyADP-ribosylation is a transient posttranslational modification of proteins, mainly catalyzed by poly(ADP-ribose)polymerase-1 (PARP-1). This highly conserved nuclear protein is activated rapidly in response to DNA nick formation and promotes a fast DNA repair. Here, we examine a possible association between polyADP-ribosylation and the activity of neurotrophins and neuroprotective peptides taking part in life-or-death decisions in mammalian neurons. The presented results indicate an alternative mode of PARP-1 activation in the absence of DNA damage by neurotrophin-induced signaling mechanisms. PARP-1 was activated in rat cerebral cortical neurons briefly exposed to NGF-related nerve growth factors and to the neuroprotective peptides NAP (the peptide NAPVSIPQ, derived from the activity-dependent neuroprotective protein ADNP) and ADNF-9 (the peptide SALLRSIPA, derived from the activity-dependent neurotrophic factor ADNF) In addition, polyADP-ribosylation was involved in the neurotrophic activity of NGF-induced and NAP-induced neurite outgrowth in differentiating pheochromocytoma 12 cells as well as in the neuroprotective activity of NAP in neurons treated with the Alzheimer's disease neurotoxin β-amyloid. A fast loosening of the highly condensed chromatin structure by polyADP-ribosylation of histone H1, which renders DNA accessible to transcription and repair, may underlie the role of polyADP-ribosylation in neurotrophic activity." @default.
- W2029253143 created "2016-06-24" @default.
- W2029253143 creator A5006745559 @default.
- W2029253143 creator A5036117185 @default.
- W2029253143 creator A5046110690 @default.
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- W2029253143 creator A5054556880 @default.
- W2029253143 creator A5054754366 @default.
- W2029253143 creator A5067213614 @default.
- W2029253143 date "2005-08-10" @default.
- W2029253143 modified "2023-10-05" @default.
- W2029253143 title "PolyADP-Ribosylation Is Involved in Neurotrophic Activity" @default.
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