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- W2029264690 abstract "Adult male rats were maintained on normal (20% casein), protein-free (0% casein), high protein (50% casein), deficient protein (20% zein), and a supplemented, deficient protein (20% zein plus L-lysine L-tryptophan) diets. Rats on a protein-free diet excreted approximately 1 mg α2u/24 h compared with a normal of 10–15 mg/24 h. Depleted rats placed on a 20% casein diets showed a rapid restoration of the normal α2u excretion as well as total urinary proteins. Accumulation of α2u in the blood serum was measured in nephrectomized rats. Rats on a 0% casein diet accumulated only 30% of the α2u compared to normals. On a 50% casein diet, rats excreted 30–50 mg α2u/24h. However, the accumulation was normal in the serum of nephrectomized rats. A high protein diet did not stimulate α2u synthesis but probably increased the renal loss of all urinary proteins. The excretion of α2u on a zein diet was reduced to the same degree as with the protein-free diet. Supplementation with lysine and tryptophan restored the capacity to eliminate α2u to near normal levels. Accumulation of α2u in the serum of nephrectomized rats kept on the zein diets showed that the effect was to suppress the synthesis of the α2u. Supplementation restored the biosynthesis of α2u. We conclude that the effect of dietary protein on the excretion of urinary proteins in the adult male rat is caused in large part by an influence on the hepatic biosynthesis of α2u. The biosynthesis of this protein, which represents approximately 30% of the total urinary proteins, is dependent on an adequate supply of dietary protein." @default.
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- W2029264690 date "1975-11-10" @default.
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- W2029264690 title "The effect of dietary protein on the excretion of α2u, the sex-dependent protein of the adult male rat" @default.
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- W2029264690 doi "https://doi.org/10.1016/0304-4165(75)90286-x" @default.
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