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- W2029272886 abstract "Osteoarthritis is characterized by the progressive destruction of articular cartilage and subchondral bone and synovial reaction. Radiological findings that form the basis of the diagnosis of osteoarthritis are poorly sensitive for detecting early disease and monitoring progression of joint damage. New specific and sensitive biochemical markers of cartilage and synovial tissue turnover, including assays for Type II collagen synthesis and degradation, have been developed. Recent prospective studies indicate that blood and urine levels of these new markers are associated with the progression of joint damage. Biological markers respond rapidly to treatment, and thus will certainly play an important role in the development and monitoring of disease-modifying therapies. As osteoarthritis involves different tissues and complex biological processes, a combination of different biochemical markers appears to be the most promising diagnostic strategy." @default.
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- W2029272886 date "2006-08-01" @default.
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- W2029272886 title "New biochemical markers of osteoarthritis" @default.
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