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• W2029273393 endingPage "1719" @default.
• W2029273393 startingPage "1716" @default.
• W2029273393 abstract "The models and simulation tools available to design functionally complex synthetic biological devices are very limited. We formulated a design-driven approach that used mechanistic modeling and kinetic RNA folding simulations to engineer RNA-regulated genetic devices that control gene expression. Ribozyme and metabolite-controlled, aptazyme-regulated expression devices with quantitatively predictable functions were assembled from components characterized in vitro, in vivo, and in silico. The models and design strategy were verified by constructing 28 Escherichia coli expression devices that gave excellent quantitative agreement between the predicted and measured gene expression levels (r = 0.94). These technologies were applied to engineer RNA-regulated controls in metabolic pathways. More broadly, we provide a framework for studying RNA functions and illustrate the potential for the use of biochemical and biophysical modeling to develop biological design methods." @default.
• W2029273393 created "2016-06-24" @default.
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• W2029273393 date "2011-12-23" @default.
• W2029273393 modified "2023-10-08" @default.
• W2029273393 title "Model-Driven Engineering of RNA Devices to Quantitatively Program Gene Expression" @default.
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• W2029273393 doi "https://doi.org/10.1126/science.1212209" @default.
• W2029273393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22194579" @default.
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