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- W2029282603 abstract "Nitric oxide (NO) prevents vascular smooth muscle cell (VSMC) proliferation by causing G0/G1 cell cycle arrest. We have previously shown that the ubiquitin-conjugating enzyme UbcH10 directly regulates VSMC proliferation and that NO decreases UbcH10 levels by increasing levels of ubiquitinated UbcH10 (Ub-UbcH10). What remains unknown is the mechanism by which NO does this. Since the anaphase-promoting complex (APC) is the ubiquitin ligase binding partner to UbcH10, we hypothesize that NO increases APC activity, leading to increased levels of Ub-UbcH10." @default.
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- W2029282603 date "2014-02-01" @default.
- W2029282603 modified "2023-09-26" @default.
- W2029282603 title "Nitric Oxide Induces Ubiquitination of UbcH10 by Increasing the Activity of the Anaphase-Promoting Complex" @default.
- W2029282603 doi "https://doi.org/10.1016/j.jss.2013.11.554" @default.
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