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- W2029287162 abstract "A 12-step synthesis of the angiogenesis inhibitory marine metabolite ageladine A is reported. The key steps include a 6π-1-azatriene electrocyclization for formation of the pyridine ring and a Suzuki−Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloroimidazopyridine. In addition, an assessment of the biological activity of a variety of synthetic analogues of ageladine A prepared during this synthesis is described." @default.
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- W2029287162 date "2007-06-01" @default.
- W2029287162 modified "2023-10-07" @default.
- W2029287162 title "Application of a 6π-1-Azatriene Electrocyclization Strategy to the Total Synthesis of the Marine Sponge Metabolite Ageladine A and Biological Evaluation of Synthetic Analogues" @default.
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- W2029287162 doi "https://doi.org/10.1021/jo0707232" @default.
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