FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029287287> ?p ?o ?g. }

• W2029287287 abstract "About 15 to 20% of breast cancer cases overexpress human epidermal growth factor receptor-2 (HER-2). This overexpression is associated with poor clinical prognosis but therapeutic success of trastuzumab or lapatinib. HER-2 extracellular domain (ECD) undergoes a proteolytic cleavage and is shed into biologic fluid as a circulating antigen called ECD/HER-2, which can be detected by immunochemical assays.The aim of our review was to determine the clinical usefulness of ECD/HER-2 measurement in the management of breast cancer patients.A Pubmed search for publications in English or French was carried out until March 31, 2010 (69 original articles and 8 reviews).The measurement of ECD/HER-2 concentration does not exempt from the pathological determination of HER-2 expression in tumors; some HER-2 negative tumors are associated with high levels of ECD/HER-2, on the other hand, some HER-2 positive tumors present low levels of ECD/HER-2. The concentration of ECD/HER-2 is correlated to disease progression, since 10% of loco-regional breast cancers and more than a third of metastatic breast cancers have high levels of ECD/HER-2. The elevation of ECD/HER-2 levels generally occurs several months before the diagnosis of symptomatic metastases. The relevance of ECD/HER-2 measurements during chemotherapy, hormone therapy and trastuzumab treatment remains uncertain. Similarly, it is not commonly agreed that high levels of ECD/HER-2 before any treatment in the case of an early breast cancer, is an independent prognostic factor.A close analysis of a variety of pathological, biochemical, clinical and methodological data may explain these discrepancies.New prospective studies using immunochemical measurements of ECD/HER-2 (with a consensual threshold) and based on both detailed pathological analyses and a comprehensive collection of clinical data are still required to establish the clinical usefulness of circulating ECD/HER-2 measurement for breast cancer patients' management." @default.
• W2029287287 created "2016-06-24" @default.
• W2029287287 creator A5016509511 @default.
• W2029287287 creator A5025288980 @default.
• W2029287287 creator A5029774842 @default.
• W2029287287 creator A5031458774 @default.
• W2029287287 creator A5036022016 @default.
• W2029287287 creator A5036028428 @default.
• W2029287287 creator A5048821679 @default.
• W2029287287 creator A5086029815 @default.
• W2029287287 date "2011-02-01" @default.
• W2029287287 modified "2023-09-29" @default.
• W2029287287 title "Doit-on doser le marqueur circulant ECD/HER-2 chez les patientes atteintes d’un cancer mammaire ?" @default.
• W2029287287 cites W140747696 @default.
• W2029287287 cites W1574463874 @default.
• W2029287287 cites W1599285204 @default.
• W2029287287 cites W176192392 @default.
• W2029287287 cites W1764073409 @default.
• W2029287287 cites W182754908 @default.
• W2029287287 cites W1852564520 @default.
• W2029287287 cites W1886195314 @default.
• W2029287287 cites W1901376003 @default.
• W2029287287 cites W1904902777 @default.
• W2029287287 cites W1907754752 @default.
• W2029287287 cites W1922272927 @default.
• W2029287287 cites W1965781424 @default.
• W2029287287 cites W1973033337 @default.
• W2029287287 cites W1975936012 @default.
• W2029287287 cites W1976090068 @default.
• W2029287287 cites W1978417169 @default.
• W2029287287 cites W1981646564 @default.
• W2029287287 cites W1986214131 @default.
• W2029287287 cites W1987380783 @default.
• W2029287287 cites W1988289423 @default.
• W2029287287 cites W1998297552 @default.
• W2029287287 cites W1999461982 @default.
• W2029287287 cites W2003792276 @default.
• W2029287287 cites W2003985395 @default.
• W2029287287 cites W2005084132 @default.
• W2029287287 cites W2012877952 @default.
• W2029287287 cites W2016552610 @default.
• W2029287287 cites W2026342861 @default.
• W2029287287 cites W2029349813 @default.
• W2029287287 cites W2029419286 @default.
• W2029287287 cites W2035484878 @default.
• W2029287287 cites W2039359329 @default.
• W2029287287 cites W2041296576 @default.
• W2029287287 cites W2050068687 @default.
• W2029287287 cites W2050411049 @default.
• W2029287287 cites W2052034196 @default.
• W2029287287 cites W2058370043 @default.
• W2029287287 cites W2064347883 @default.
• W2029287287 cites W2065064603 @default.
• W2029287287 cites W2069724886 @default.
• W2029287287 cites W2072368645 @default.
• W2029287287 cites W2073604089 @default.
• W2029287287 cites W2081271018 @default.
• W2029287287 cites W2084923342 @default.
• W2029287287 cites W2088646621 @default.
• W2029287287 cites W2089504691 @default.
• W2029287287 cites W2089931896 @default.
• W2029287287 cites W2092429540 @default.
• W2029287287 cites W2096692194 @default.
• W2029287287 cites W2099989027 @default.
• W2029287287 cites W2100375606 @default.
• W2029287287 cites W2105764874 @default.
• W2029287287 cites W2106712257 @default.
• W2029287287 cites W2106949434 @default.
• W2029287287 cites W2116048238 @default.
• W2029287287 cites W2119801958 @default.
• W2029287287 cites W2122812256 @default.
• W2029287287 cites W2123299533 @default.
• W2029287287 cites W2126619703 @default.
• W2029287287 cites W2129530019 @default.
• W2029287287 cites W2130074283 @default.
• W2029287287 cites W2130900820 @default.
• W2029287287 cites W2132105964 @default.
• W2029287287 cites W2137008427 @default.
• W2029287287 cites W2137399990 @default.
• W2029287287 cites W2138812894 @default.
• W2029287287 cites W2141217952 @default.
• W2029287287 cites W2141393790 @default.
• W2029287287 cites W2143362749 @default.
• W2029287287 cites W2146050250 @default.
• W2029287287 cites W2146406055 @default.
• W2029287287 cites W2148689234 @default.
• W2029287287 cites W2151631271 @default.
• W2029287287 cites W2154027407 @default.
• W2029287287 cites W2156251518 @default.
• W2029287287 cites W2158437743 @default.
• W2029287287 cites W2159363679 @default.
• W2029287287 cites W2162642395 @default.
• W2029287287 cites W2168106779 @default.
• W2029287287 cites W2172265576 @default.
• W2029287287 cites W2183798533 @default.
• W2029287287 cites W2209801357 @default.
• W2029287287 cites W2254593122 @default.
• W2029287287 cites W2263422734 @default.
• W2029287287 cites W2268321868 @default.
• W2029287287 cites W2340898473 @default.

• next