FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029294837> ?p ?o ?g. }

• W2029294837 endingPage "1050" @default.
• W2029294837 startingPage "1042" @default.
• W2029294837 abstract "A single intracerebroventricular injection of β-amyloid 25–35 peptide (Aβ25–35) (9 nmol/mouse) induces the spatial cognitive deterioration and approximately 50% loss of pyramidal cells in hippocampal CA1 region within 1 week. The present study focused on exploring the effects of neurosteroid pregnenolone sulfate (PREGS), in comparison with the selective agonists of sigma-1 receptor (σ1R) and α7 nicotinic acetylcholine receptor (α7nAChR), on the cognitive deficits and the death of pyramidal cells in Aβ25–35-mice. Herein, we reported that the administration of PREGS (1–100 mg/kg) for 7 days after Aβ25–35-injection could dose-dependently ameliorate the cognitive deficits and attenuate the apoptosis of pyramidal cells. Either the σ1R antagonist NE100 or the α7nAChR antagonist MLA could block the neuroprotection of PREGS in Aβ25–35-mice. Both the σ1R agonist PRE084 and the α7nAChR agonist DMXB could mimic the PREGS-neuroprotection against the Aβ25–35-neurotoxicity. The neuroprotection of PRE084 was attenuated by MLA, but the DMXB-action was insensitive to NE100. The neuroprotection of PREGS, PRE084 or DMXB was blocked by the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002, whereas only the effect of PREGS or PRE084 was sensitive to the MAPK/ERK kinase (MEK) inhibitor U0126. PREGS prevented Aβ25–35-inhibited Akt (Serine/threonine kinase) phosphorylation leading to increase in caspase-3 activity, which was σ1R- and α7nAChR-dependent. By contrast, PREGS-rescued reduction of extracellular signal-related kinase-2 (ERK2) phosphorylation in Aβ25–35-mice only required the activation of σ1R. Blockage of PREGS-neuroprotection by LY294002 significantly attenuated its anti-amnesic effect in Aβ25–35-mice. The findings indicate that the anti-amnesic effects of PREGS in Aβ25–35-mice depend on the σ1R- and α7nAChR-mediated neuroprotection." @default.
• W2029294837 created "2016-06-24" @default.
• W2029294837 creator A5010738468 @default.
• W2029294837 creator A5017020283 @default.
• W2029294837 creator A5033729931 @default.
• W2029294837 creator A5070720384 @default.
• W2029294837 creator A5072985467 @default.
• W2029294837 creator A5084410970 @default.
• W2029294837 date "2012-11-01" @default.
• W2029294837 modified "2023-10-14" @default.
• W2029294837 title "Anti-amnesic effect of neurosteroid PREGS in Aβ25–35-injected mice through σ1 receptor- and α7nAChR-mediated neuroprotection" @default.
• W2029294837 cites W1500642137 @default.
• W2029294837 cites W1505473665 @default.
• W2029294837 cites W1968576491 @default.
• W2029294837 cites W1970479727 @default.
• W2029294837 cites W1980216102 @default.
• W2029294837 cites W1980854377 @default.
• W2029294837 cites W1981475053 @default.
• W2029294837 cites W1981545549 @default.
• W2029294837 cites W1984917548 @default.
• W2029294837 cites W1987430250 @default.
• W2029294837 cites W1987725130 @default.
• W2029294837 cites W1988522729 @default.
• W2029294837 cites W1989888504 @default.
• W2029294837 cites W1992500239 @default.
• W2029294837 cites W1994121039 @default.
• W2029294837 cites W1994463266 @default.
• W2029294837 cites W1994600803 @default.
• W2029294837 cites W1998685086 @default.
• W2029294837 cites W1999514420 @default.
• W2029294837 cites W2007631668 @default.
• W2029294837 cites W2009806490 @default.
• W2029294837 cites W2019521819 @default.
• W2029294837 cites W2020834255 @default.
• W2029294837 cites W2022312204 @default.
• W2029294837 cites W2023500161 @default.
• W2029294837 cites W2023786216 @default.
• W2029294837 cites W2025014038 @default.
• W2029294837 cites W2026070248 @default.
• W2029294837 cites W2029279326 @default.
• W2029294837 cites W2031211058 @default.
• W2029294837 cites W2038357865 @default.
• W2029294837 cites W2038360643 @default.
• W2029294837 cites W2040991643 @default.
• W2029294837 cites W2041204873 @default.
• W2029294837 cites W2042429529 @default.
• W2029294837 cites W2044291313 @default.
• W2029294837 cites W2048832465 @default.
• W2029294837 cites W2049167261 @default.
• W2029294837 cites W2049702445 @default.
• W2029294837 cites W2049876394 @default.
• W2029294837 cites W2052619557 @default.
• W2029294837 cites W2059583297 @default.
• W2029294837 cites W2064767298 @default.
• W2029294837 cites W2066385861 @default.
• W2029294837 cites W2071791804 @default.
• W2029294837 cites W2077887990 @default.
• W2029294837 cites W2078203056 @default.
• W2029294837 cites W2078890238 @default.
• W2029294837 cites W2082317154 @default.
• W2029294837 cites W2083105433 @default.
• W2029294837 cites W2083480979 @default.
• W2029294837 cites W2086468822 @default.
• W2029294837 cites W2092403972 @default.
• W2029294837 cites W2095553416 @default.
• W2029294837 cites W2113663369 @default.
• W2029294837 cites W2122346217 @default.
• W2029294837 cites W2130144581 @default.
• W2029294837 cites W2145087907 @default.
• W2029294837 cites W2145135770 @default.
• W2029294837 cites W2164467473 @default.
• W2029294837 doi "https://doi.org/10.1016/j.neuropharm.2012.07.035" @default.
• W2029294837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22884465" @default.
• W2029294837 hasPublicationYear "2012" @default.
• W2029294837 type Work @default.
• W2029294837 sameAs 2029294837 @default.
• W2029294837 citedByCount "61" @default.
• W2029294837 countsByYear W20292948372013 @default.
• W2029294837 countsByYear W20292948372014 @default.
• W2029294837 countsByYear W20292948372015 @default.
• W2029294837 countsByYear W20292948372016 @default.
• W2029294837 countsByYear W20292948372017 @default.
• W2029294837 countsByYear W20292948372018 @default.
• W2029294837 countsByYear W20292948372019 @default.
• W2029294837 countsByYear W20292948372020 @default.
• W2029294837 countsByYear W20292948372021 @default.
• W2029294837 countsByYear W20292948372022 @default.
• W2029294837 countsByYear W20292948372023 @default.
• W2029294837 crossrefType "journal-article" @default.
• W2029294837 hasAuthorship W2029294837A5010738468 @default.
• W2029294837 hasAuthorship W2029294837A5017020283 @default.
• W2029294837 hasAuthorship W2029294837A5033729931 @default.
• W2029294837 hasAuthorship W2029294837A5070720384 @default.
• W2029294837 hasAuthorship W2029294837A5072985467 @default.
• W2029294837 hasAuthorship W2029294837A5084410970 @default.
• W2029294837 hasConcept C126322002 @default.
• W2029294837 hasConcept C134018914 @default.
• W2029294837 hasConcept C168258287 @default.

• next