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• W2029295217 abstract "To isolate pathogen-associated molecular patterns (PAMPs)-binding molecules, the bacterium, Staphylococcus aureus was used as an affinity matrix to find bacteria-binding proteins in the plasma of the freshwater crayfish, Pacifastacus leniusculus. Two new bacteria-binding ficolin-like proteins (FLPs) were identified by 2-DE and MS analysis. The FLPs have a fibrinogen-related domain (FReD) in their C-terminal and a repeat region in their N-terminal regions with putative structural similarities to the collagen-like domain of vertebrate ficolins and mannose binding lectins (MBLs). Phylogenetic analysis shows that the newly isolated crayfish FLP1 and FLP2 cluster separately from other FReD-containing proteins. A tissue distribution study showed that the mRNA expression of FLP occurred mainly in the hematopoietic tissue (Hpt) and in the hepatopancreas. Recombinant FLPs exhibited agglutination activity of Gram-negative bacteria Escherichia coli and Aeromonas hydrophila in the presence of Ca2+. The FLPs could bind to A. hydrophila, E. coli as well as S. aureus as judged by bacteria adsorption. Moreover, the FLPs may help crayfish to clear Gram-negative bacteria, but not Gram-positive bacteria which had been injected into the hemolymph. When Gram-negative bacteria coated with FLPs were incubated with Hpt cells, a lower death rate of the cells was found compared with control treatment. Our results suggest that FLPs function as pattern recognition receptors in the immune response of crayfish." @default.
• W2029295217 created "2016-06-24" @default.
• W2029295217 creator A5029179499 @default.
• W2029295217 creator A5032298209 @default.
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• W2029295217 date "2011-05-20" @default.
• W2029295217 modified "2023-10-15" @default.
• W2029295217 title "Two novel ficolin-like proteins act as pattern recognition receptors for invading pathogens in the freshwater crayfish<i>Pacifastacus leniusculus</i>" @default.
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• W2029295217 doi "https://doi.org/10.1002/pmic.201000728" @default.
• W2029295217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21598394" @default.
• W2029295217 hasPublicationYear "2011" @default.
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