Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029295703> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2029295703 endingPage "43" @default.
- W2029295703 startingPage "40" @default.
- W2029295703 abstract "Gengraf capsule, an AB-rated generic cyclosporine for Neoral, has been shown to be bioequivalent in previous studies. The objective of this study was to evaluate the pharmacokinetics and bioequivalence of Gengraf and Neoral in stable Chinese renal allograft recipients In a prospective, open-label, two-period design study, 20 renal allograft recipients receiving stable doses of Neoral were recruited. Subjects continued their Neoral regimen during period I (days 1-14). They were then switched from Neoral on a milligram-for-milligram basis to Gengraf during period II (days 15-28). Four-hour pharmacokinetic parameters (concentration before dosing [Ctrough], maximum blood concentration [Cmax], time to maximum concentration [Tmax], and area under the blood concentration-versus-time curve [AUC0-4]) were taken on days 1, 8, 21, and 28. Biochemical parameters were also evaluated. There was no significant difference in the pharmacokinetics of Gengraf (Ctrough, Tmax, Cmax, and AUC0-4) as compared with that of Neoral in stable renal transplant recipients. The bioequivalent capsules were interchangeable with respect to Ctrough, Cmax and AUC0-4. The 90% confidence intervals of the ratio of Ctrough, Cmax, Tmax, and AUC0-4 of Gengraf and Neoral were 0.94 to 1.21 for Ctrough, 0.97 to 1.20 for Cmax, and 0.97 to 1.20 for AUC0-4. Ctrough and C2 remained stable throughout the study without any dosage adjustments. Gengraf was well tolerated, and had a comparable safety profile as Neoral. Gengraf are bioequivalent to Neoral. Gengraf is well tolerated and interchangeable with Neoral in stable Chinese renal allograft recipients." @default.
- W2029295703 created "2016-06-24" @default.
- W2029295703 creator A5013625728 @default.
- W2029295703 creator A5033718553 @default.
- W2029295703 creator A5039429698 @default.
- W2029295703 creator A5041812274 @default.
- W2029295703 creator A5047546336 @default.
- W2029295703 creator A5048222625 @default.
- W2029295703 creator A5052455950 @default.
- W2029295703 creator A5058280153 @default.
- W2029295703 creator A5072300300 @default.
- W2029295703 date "2003-04-01" @default.
- W2029295703 modified "2023-09-25" @default.
- W2029295703 title "The pharmacokinetics and bioequivalence of Gengraf and Neoral in stable renal transplant recipients" @default.
- W2029295703 cites W2000720198 @default.
- W2029295703 cites W2000770163 @default.
- W2029295703 cites W2026235158 @default.
- W2029295703 cites W2041951312 @default.
- W2029295703 cites W2056810545 @default.
- W2029295703 cites W2327458423 @default.
- W2029295703 cites W2331198516 @default.
- W2029295703 cites W2427581785 @default.
- W2029295703 doi "https://doi.org/10.1016/s1561-5413(09)60102-2" @default.
- W2029295703 hasPublicationYear "2003" @default.
- W2029295703 type Work @default.
- W2029295703 sameAs 2029295703 @default.
- W2029295703 citedByCount "1" @default.
- W2029295703 countsByYear W20292957032012 @default.
- W2029295703 crossrefType "journal-article" @default.
- W2029295703 hasAuthorship W2029295703A5013625728 @default.
- W2029295703 hasAuthorship W2029295703A5033718553 @default.
- W2029295703 hasAuthorship W2029295703A5039429698 @default.
- W2029295703 hasAuthorship W2029295703A5041812274 @default.
- W2029295703 hasAuthorship W2029295703A5047546336 @default.
- W2029295703 hasAuthorship W2029295703A5048222625 @default.
- W2029295703 hasAuthorship W2029295703A5052455950 @default.
- W2029295703 hasAuthorship W2029295703A5058280153 @default.
- W2029295703 hasAuthorship W2029295703A5072300300 @default.
- W2029295703 hasConcept C112705442 @default.
- W2029295703 hasConcept C126894567 @default.
- W2029295703 hasConcept C22979827 @default.
- W2029295703 hasConcept C2777288759 @default.
- W2029295703 hasConcept C42404028 @default.
- W2029295703 hasConcept C71924100 @default.
- W2029295703 hasConcept C98274493 @default.
- W2029295703 hasConceptScore W2029295703C112705442 @default.
- W2029295703 hasConceptScore W2029295703C126894567 @default.
- W2029295703 hasConceptScore W2029295703C22979827 @default.
- W2029295703 hasConceptScore W2029295703C2777288759 @default.
- W2029295703 hasConceptScore W2029295703C42404028 @default.
- W2029295703 hasConceptScore W2029295703C71924100 @default.
- W2029295703 hasConceptScore W2029295703C98274493 @default.
- W2029295703 hasIssue "1" @default.
- W2029295703 hasLocation W20292957031 @default.
- W2029295703 hasOpenAccess W2029295703 @default.
- W2029295703 hasPrimaryLocation W20292957031 @default.
- W2029295703 hasRelatedWork W1991854939 @default.
- W2029295703 hasRelatedWork W2018313535 @default.
- W2029295703 hasRelatedWork W2080969318 @default.
- W2029295703 hasRelatedWork W2104641112 @default.
- W2029295703 hasRelatedWork W2351154051 @default.
- W2029295703 hasRelatedWork W2354680669 @default.
- W2029295703 hasRelatedWork W2359939078 @default.
- W2029295703 hasRelatedWork W2365455541 @default.
- W2029295703 hasRelatedWork W2411695865 @default.
- W2029295703 hasRelatedWork W3089081291 @default.
- W2029295703 hasVolume "5" @default.
- W2029295703 isParatext "false" @default.
- W2029295703 isRetracted "false" @default.
- W2029295703 magId "2029295703" @default.
- W2029295703 workType "article" @default.