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- W2029299707 abstract "HIV-1 integrase (IN) is essential for the replication of HIV-1 in human cells. At present, the complete structure of complex IN–DNA has not been resolved. In this paper, a HIV-1 IN tetramer model was built with homology modeling and molecular dynamics simulation approach, in which two Mg2+ ions were reasonably located in each catalytic core domain. Moreover, it was found that the AB and CD chains of HIV-1 IN tetramer were different in the structures and metal ions of HIV-1 IN tetramer might have great influences on DNA locating on IN. These findings may provide a more complete structural basis for guiding drug discovery and revealing integration mechanism." @default.
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- W2029299707 date "2005-11-01" @default.
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- W2029299707 title "Constructing HIV-1 integrase tetramer and exploring influences of metal ions on forming integrase–DNA complex" @default.
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- W2029299707 doi "https://doi.org/10.1016/j.bbrc.2005.08.274" @default.
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