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- W2029300043 abstract "Hepatocyte growth factor receptor (HGFR), the product of the MET gene, plays an important role in normal cellular function and oncogenesis. In cancer, HGFR has been implicated in cellular proliferation, cell survival, invasion, cell motility, metastasis and angiogenesis. Activation of HGFR can occur through binding to its ligand, hepatocyte growth factor (HGF), overexpression/amplification, mutation, and/or decreased degradation. Amplification of HGFR can occur de novo or in resistance to therapy. Mutations of HGFR have been described in the tyrosine kinase domain, juxtamembrane domain, or semaphorin domain in a number of tumors. These mutations appear to have gain of function, and also reflect differential sensitivity to therapeutic inhibition. There have been various drugs developed to target HGFR, including antibodies to HGFR/HGF, small-molecule inhibitors against the tyrosine kinase domain of HGFR and downstream targets. Different HGFR inhibitors are currently in clinical trials in lung cancer and a number of solid tumors. Several phase I trials have already been completed, and two specific trials have been reported combining HGFR with epidermal growth factor receptor (EGFR) inhibition in non-small cell lung cancer. In particular, trials involving MetMAb and ARQ197 (tivantinib) have gained interest. Ultimately, as individualized therapies become a reality for cancers, HGFR will be an important molecular target." @default.
- W2029300043 created "2016-06-24" @default.
- W2029300043 creator A5003826371 @default.
- W2029300043 creator A5021376250 @default.
- W2029300043 creator A5031721461 @default.
- W2029300043 creator A5034151974 @default.
- W2029300043 creator A5089913936 @default.
- W2029300043 date "2011-06-02" @default.
- W2029300043 modified "2023-09-25" @default.
- W2029300043 title "The role of the c-Met pathway in lung cancer and the potential for targeted therapy" @default.
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- W2029300043 doi "https://doi.org/10.1177/1758834011408636" @default.
- W2029300043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3150066" @default.