Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029319167> ?p ?o ?g. }
- W2029319167 endingPage "13469" @default.
- W2029319167 startingPage "13454" @default.
- W2029319167 abstract "Abnormal deposition and intercellular propagation of α-synuclein plays a central role in the pathogenesis of disorders such as Parkinson's Disease (PD) and dementia with Lewy bodies (DLB). Previous studies demonstrated that immunization against α-synuclein resulted in reduced α-synuclein accumulation and synaptic loss in a transgenic (tg) mouse model, highlighting the potential for immunotherapy. However, the mechanism by which immunization prevents synucleinopathy-associated deficits remains unknown. Here, we show that antibodies against α-synuclein specifically target and aid in clearance of extracellular α-synuclein proteins by microglia, thereby preventing their actions on neighboring cells. Antibody-assisted clearance occurs mainly in microglia through the Fcγ receptor, and not in neuronal cells or astrocytes. Stereotaxic administration of antibody into the brains of α-synuclein tg mice prevented neuron-to-astroglia transmission of α-synuclein and led to increased localization of α-synuclein and the antibody in microglia. Furthermore, passive immunization with α-synuclein antibody reduced neuronal and glial accumulation of α-synuclein and ameliorated neurodegeneration and behavioral deficits associated with α-synuclein overexpression. These findings provide an underlying mechanistic basis for immunotherapy for PD/DLB and suggest extracellular forms of α-synuclein as potential therapeutic targets." @default.
- W2029319167 created "2016-06-24" @default.
- W2029319167 creator A5002743312 @default.
- W2029319167 creator A5035768302 @default.
- W2029319167 creator A5037007617 @default.
- W2029319167 creator A5041374879 @default.
- W2029319167 creator A5044243280 @default.
- W2029319167 creator A5058385646 @default.
- W2029319167 creator A5059245902 @default.
- W2029319167 creator A5071949326 @default.
- W2029319167 creator A5074775445 @default.
- W2029319167 date "2012-09-26" @default.
- W2029319167 modified "2023-10-13" @default.
- W2029319167 title "Antibody-Aided Clearance of Extracellular -Synuclein Prevents Cell-to-Cell Aggregate Transmission" @default.
- W2029319167 cites W1498285003 @default.
- W2029319167 cites W1522048223 @default.
- W2029319167 cites W1528113046 @default.
- W2029319167 cites W1558808632 @default.
- W2029319167 cites W1567490604 @default.
- W2029319167 cites W1579132652 @default.
- W2029319167 cites W1597819025 @default.
- W2029319167 cites W1696575834 @default.
- W2029319167 cites W1903287340 @default.
- W2029319167 cites W1965295915 @default.
- W2029319167 cites W1965888147 @default.
- W2029319167 cites W1966409098 @default.
- W2029319167 cites W1968337792 @default.
- W2029319167 cites W1969277178 @default.
- W2029319167 cites W1969584460 @default.
- W2029319167 cites W1971349333 @default.
- W2029319167 cites W1973190490 @default.
- W2029319167 cites W1977267085 @default.
- W2029319167 cites W1978737376 @default.
- W2029319167 cites W1989208474 @default.
- W2029319167 cites W1991993391 @default.
- W2029319167 cites W1995549336 @default.
- W2029319167 cites W1995924485 @default.
- W2029319167 cites W1996821202 @default.
- W2029319167 cites W1997524825 @default.
- W2029319167 cites W1999638129 @default.
- W2029319167 cites W2001369807 @default.
- W2029319167 cites W2004875827 @default.
- W2029319167 cites W2014413787 @default.
- W2029319167 cites W2015957622 @default.
- W2029319167 cites W2021155980 @default.
- W2029319167 cites W2021233665 @default.
- W2029319167 cites W2022160988 @default.
- W2029319167 cites W2023048174 @default.
- W2029319167 cites W2024262813 @default.
- W2029319167 cites W2025922492 @default.
- W2029319167 cites W2029978572 @default.
- W2029319167 cites W2039172739 @default.
- W2029319167 cites W2044407202 @default.
- W2029319167 cites W2046885195 @default.
- W2029319167 cites W2047885160 @default.
- W2029319167 cites W2049737588 @default.
- W2029319167 cites W2050647292 @default.
- W2029319167 cites W2051564559 @default.
- W2029319167 cites W2052222339 @default.
- W2029319167 cites W2059261643 @default.
- W2029319167 cites W2060851420 @default.
- W2029319167 cites W2063198655 @default.
- W2029319167 cites W2063553621 @default.
- W2029319167 cites W2065236536 @default.
- W2029319167 cites W2080576667 @default.
- W2029319167 cites W2080949995 @default.
- W2029319167 cites W2084661849 @default.
- W2029319167 cites W2088198588 @default.
- W2029319167 cites W2089900719 @default.
- W2029319167 cites W2090240161 @default.
- W2029319167 cites W2095376584 @default.
- W2029319167 cites W2098069894 @default.
- W2029319167 cites W2099340107 @default.
- W2029319167 cites W2108060249 @default.
- W2029319167 cites W2110554184 @default.
- W2029319167 cites W2111219019 @default.
- W2029319167 cites W2117626437 @default.
- W2029319167 cites W2122564376 @default.
- W2029319167 cites W2123869107 @default.
- W2029319167 cites W2128862391 @default.
- W2029319167 cites W2139319426 @default.
- W2029319167 cites W2152446053 @default.
- W2029319167 cites W2159247740 @default.
- W2029319167 cites W2162353774 @default.
- W2029319167 cites W2164627569 @default.
- W2029319167 cites W2172071810 @default.
- W2029319167 doi "https://doi.org/10.1523/jneurosci.1292-12.2012" @default.
- W2029319167 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3752153" @default.
- W2029319167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23015436" @default.
- W2029319167 hasPublicationYear "2012" @default.
- W2029319167 type Work @default.
- W2029319167 sameAs 2029319167 @default.
- W2029319167 citedByCount "284" @default.
- W2029319167 countsByYear W20293191672013 @default.
- W2029319167 countsByYear W20293191672014 @default.
- W2029319167 countsByYear W20293191672015 @default.
- W2029319167 countsByYear W20293191672016 @default.
- W2029319167 countsByYear W20293191672017 @default.