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- W2029326515 endingPage "287" @default.
- W2029326515 startingPage "239" @default.
- W2029326515 abstract "Animals are motivated to choose environmental options that can best satisfy current needs. To explain such choices, this paper introduces the MOTIVATOR (Matching Objects To Internal VAlues Triggers Option Revaluations) neural model. MOTIVATOR describes cognitive–emotional interactions between higher-order sensory cortices and an evaluative neuraxis composed of the hypothalamus, amygdala, and orbitofrontal cortex. Given a conditioned stimulus (CS), the model amygdala and lateral hypothalamus interact to calculate the expected current value of the subjective outcome that the CS predicts, constrained by the current state of deprivation or satiation. The amygdala relays the expected value information to orbitofrontal cells that receive inputs from anterior inferotemporal cells, and medial orbitofrontal cells that receive inputs from rhinal cortex. The activations of these orbitofrontal cells code the subjective values of objects. These values guide behavioral choices. The model basal ganglia detect errors in CS-specific predictions of the value and timing of rewards. Excitatory inputs from the pedunculopontine nucleus interact with timed inhibitory inputs from model striosomes in the ventral striatum to regulate dopamine burst and dip responses from cells in the substantia nigra pars compacta and ventral tegmental area. Learning in cortical and striatal regions is strongly modulated by dopamine. The model is used to address tasks that examine food-specific satiety, Pavlovian conditioning, reinforcer devaluation, and simultaneous visual discrimination. Model simulations successfully reproduce discharge dynamics of known cell types, including signals that predict saccadic reaction times and CS-dependent changes in systolic blood pressure." @default.
- W2029326515 created "2016-06-24" @default.
- W2029326515 creator A5042282723 @default.
- W2029326515 creator A5062525056 @default.
- W2029326515 creator A5080971897 @default.
- W2029326515 date "2008-10-01" @default.
- W2029326515 modified "2023-09-27" @default.
- W2029326515 title "Dopaminergic and non-dopaminergic value systems in conditioning and outcome-specific revaluation" @default.
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