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• W2029328131 startingPage "2669" @default.
• W2029328131 abstract "Treatment of pigeon erythrocyte membranes with cholera toxin and NAD + enhanced the GTP stimulation and suppressed the F - activation of the adenylate cylase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1]. In the presence of NAD + labeled with 32 P in the AMP moiety the toxin catalyzed the covalent incorporation of radioactivity into membrane proteins with molecular weights ( M r s) of 200,000, 86,000, and 42,000. Extraction of toxin-treated membranes with Lubrol PX followed by affinity chromatography on a GTP-Sepharose column resulted in a 200-fold purification of the 42,000- M r labeled protein and in its complete separation from the other labeled proteins. The fraction containing the purified GTP-binding component from toxin-treated membranes conferred an enhanced GTP-stimulated activity on adenylate cyclase solubilized from nontreated membranes. Likewise, the addition of GTP-binding fraction from nontreated membranes to an enzyme solubilized from toxin-treated membranes restored F - stimulation of the adenylate cyclase. The toxin-induced modification of adenylate cyclase and the incorporation of radioactivity into the 42,000- M r protein were partially reversed upon incubation with toxin and nicotinamide at pH 6.1. The results indicate that cholera toxin affects the adenylate cyclase system by catalyzing an ADP-ribosylation of the 42,000- M r component bearing the guanyl nucleotide regulatory site." @default.
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• W2029328131 date "1978-06-01" @default.
• W2029328131 modified "2023-10-14" @default.
• W2029328131 title "Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system" @default.
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• W2029328131 doi "https://doi.org/10.1073/pnas.75.6.2669" @default.
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