FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029328864> ?p ?o ?g. }

• W2029328864 endingPage "414" @default.
• W2029328864 startingPage "408" @default.
• W2029328864 abstract "Increasing evidence shows that nerve growth factor (NGF) plays a role in the complex and fascinating linkage between the nervous and the immune systems due to its ability to modulate functions of several inflammatory cells.To investigate NGF receptor expression and NGF production and release by human CD4+ cells clones, which have primary relevance in modulating inflammatory events through their different subsets of functional phenotypes.The expression of NGF and a transmembrane tyrosine kinase (TrkA) was evaluated by immunohistochemistry and flow cytometry analysis in five T(H0), six T(H1), and five T(H2) cell clones derived from human circulating mononuclear blood cells. Moreover, the amount of NGF protein was assessed by measuring the NGF levels in culture supernatants of the T cell clones before stimulation and 48 hours after phytohemagglutinin (PHA) activation by use of an immunoenzymatic assay.Our data have shown that in unstimulated conditions, human CD4+ T cell clones express both immunoreactivity for NGF and the TrkA NGF receptor irrespective of their cytokine profile. Moreover, T(H1) and T(H2) clones, but not T(H0) clones, secrete NGF in basal conditions. PHA activation induces NGF secretion in T(H0) clones and a significant increase of NGF levels in T(H2) (p < 0.05), but not in T(H1) culture supernatants.Results obtained represent the first evidence of TrkA expression and NGF production and release in human CD4+ cell clones and suggest a possible functional role of NGF in modulating the immune and inflammatory network." @default.
• W2029328864 created "2016-06-24" @default.
• W2029328864 creator A5007986321 @default.
• W2029328864 creator A5018870384 @default.
• W2029328864 creator A5024722655 @default.
• W2029328864 creator A5026614224 @default.
• W2029328864 creator A5027310116 @default.
• W2029328864 creator A5062762750 @default.
• W2029328864 creator A5065431996 @default.
• W2029328864 creator A5081222861 @default.
• W2029328864 date "1997-09-01" @default.
• W2029328864 modified "2023-10-01" @default.
• W2029328864 title "Human CD4+ T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors" @default.
• W2029328864 cites W1546288178 @default.
• W2029328864 cites W1570658772 @default.
• W2029328864 cites W1577398114 @default.
• W2029328864 cites W1577472511 @default.
• W2029328864 cites W1675487153 @default.
• W2029328864 cites W1863695472 @default.
• W2029328864 cites W1974018090 @default.
• W2029328864 cites W1976774853 @default.
• W2029328864 cites W1985822867 @default.
• W2029328864 cites W1989588869 @default.
• W2029328864 cites W1990197546 @default.
• W2029328864 cites W1994993130 @default.
• W2029328864 cites W2009918823 @default.
• W2029328864 cites W2013460866 @default.
• W2029328864 cites W2017472765 @default.
• W2029328864 cites W2024711621 @default.
• W2029328864 cites W2037831105 @default.
• W2029328864 cites W2042030853 @default.
• W2029328864 cites W2042912378 @default.
• W2029328864 cites W2047327922 @default.
• W2029328864 cites W2049552385 @default.
• W2029328864 cites W2060265716 @default.
• W2029328864 cites W2063695629 @default.
• W2029328864 cites W2065690369 @default.
• W2029328864 cites W2067523166 @default.
• W2029328864 cites W2068892122 @default.
• W2029328864 cites W2069748621 @default.
• W2029328864 cites W2070297491 @default.
• W2029328864 cites W2074514459 @default.
• W2029328864 cites W2076742437 @default.
• W2029328864 cites W2089240348 @default.
• W2029328864 cites W2089309198 @default.
• W2029328864 cites W2091470714 @default.
• W2029328864 cites W2093759370 @default.
• W2029328864 cites W2095351296 @default.
• W2029328864 cites W2099628695 @default.
• W2029328864 cites W2112459088 @default.
• W2029328864 cites W2158159893 @default.
• W2029328864 cites W2164989026 @default.
• W2029328864 cites W2171298974 @default.
• W2029328864 cites W2176085886 @default.
• W2029328864 cites W4242118976 @default.
• W2029328864 doi "https://doi.org/10.1016/s0091-6749(97)70256-2" @default.
• W2029328864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9314355" @default.
• W2029328864 hasPublicationYear "1997" @default.
• W2029328864 type Work @default.
• W2029328864 sameAs 2029328864 @default.
• W2029328864 citedByCount "210" @default.
• W2029328864 countsByYear W20293288642012 @default.
• W2029328864 countsByYear W20293288642013 @default.
• W2029328864 countsByYear W20293288642014 @default.
• W2029328864 countsByYear W20293288642015 @default.
• W2029328864 countsByYear W20293288642016 @default.
• W2029328864 countsByYear W20293288642017 @default.
• W2029328864 countsByYear W20293288642018 @default.
• W2029328864 countsByYear W20293288642019 @default.
• W2029328864 countsByYear W20293288642020 @default.
• W2029328864 countsByYear W20293288642021 @default.
• W2029328864 countsByYear W20293288642022 @default.
• W2029328864 countsByYear W20293288642023 @default.
• W2029328864 crossrefType "journal-article" @default.
• W2029328864 hasAuthorship W2029328864A5007986321 @default.
• W2029328864 hasAuthorship W2029328864A5018870384 @default.
• W2029328864 hasAuthorship W2029328864A5024722655 @default.
• W2029328864 hasAuthorship W2029328864A5026614224 @default.
• W2029328864 hasAuthorship W2029328864A5027310116 @default.
• W2029328864 hasAuthorship W2029328864A5062762750 @default.
• W2029328864 hasAuthorship W2029328864A5065431996 @default.
• W2029328864 hasAuthorship W2029328864A5081222861 @default.
• W2029328864 hasBestOaLocation W20293288641 @default.
• W2029328864 hasConcept C126322002 @default.
• W2029328864 hasConcept C134018914 @default.
• W2029328864 hasConcept C137061746 @default.
• W2029328864 hasConcept C153911025 @default.
• W2029328864 hasConcept C170493617 @default.
• W2029328864 hasConcept C171034665 @default.
• W2029328864 hasConcept C202751555 @default.
• W2029328864 hasConcept C203014093 @default.
• W2029328864 hasConcept C2776090121 @default.
• W2029328864 hasConcept C2778423431 @default.
• W2029328864 hasConcept C2778690821 @default.
• W2029328864 hasConcept C55493867 @default.
• W2029328864 hasConcept C71924100 @default.
• W2029328864 hasConcept C86803240 @default.
• W2029328864 hasConcept C8891405 @default.

• next