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- W2029334591 abstract "<h3>To the Editor.—</h3> Cornell and Stoughton<sup>1</sup>reported excellent correlation in 20 of 23 instances between the vasoconstrictor assay for topical corticosteroid preparations (16 hours [57 600 s] nonoccluded application, single reading measurement) and paired comparison studies in psoriatic patients. Among those not demonstrating equivalence was 0.2% hydrocortisone valerate cream compared with 0.1% betamethasone valerate cream. No difference between the preparations could be detected clinically, but hydrocortisone valerate cream was superior in the skin blanching test. Gibson<sup>2</sup>stated that he found the best correlation between the vasoconstrictor assay and clinical efficacy in psoriasis using a modified skin blanching technique (six hours [21 600 s] occluded application, serial readings between seven hours [25 200 s] and 25 hours [90 000 s], followed by analysis of the areaunder-the-curve values produced). Stoughton and Cornell<sup>3</sup>replied that it would be very interesting to examine hydrocortisone valerate cream using an area-under-the-curve method. We" @default.
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- W2029334591 date "1986-12-01" @default.
- W2029334591 modified "2023-09-26" @default.
- W2029334591 title "Correlation of the Vasoconstrictor Assay and Clinical Activity in Psoriasis" @default.
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- W2029334591 doi "https://doi.org/10.1001/archderm.1986.01660240017002" @default.
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