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• W2029336121 abstract "123I neuroligands allow SPECT imaging of dopaminergic and benzodiazepine systems in various movement disorders including Parkinson’s disease, Huntington’s disease, progressive supranuclear palsy, multiple system atrophy and Wilson’s disease. Cocaine analogs with high affinity and selectivity for dopamine transporter (DAT) sites in the putamen and the caudate nucleus such as 123I-CIT [1], 123I-Altropane [2], and 123I-FPCIT [3] allow SPECT imaging of the DAT system. Likewise, dopamine transporters can be imaged with SPECT using 123I neuroligands such as 123IBZM [4], 123IBF [5], etc. Significant progress has been made in the design of high-resolution SPECT cameras dedicated for brain imaging. Also, improved physical compensation and reconstruction algorithms have been proposed, and some have been incorporated into commercial software supplied by vendors to end-users. However, in spite of advances in algorithmic designs allowing improved quantitative accuracy, absolute quantitation of DAT or D2 has been and is still very challenging with SPECT, unlike PET, due to the difficulty to accurately and simply compensate for image degrading factors such as attenuation, scatter, limited spatial resolution and low sensitivity [6]. Sensitivity is an important impediment against dynamic brain SPECT imaging which is required to achieve absolute quantitation of the distributions of many of these neuroligands. Photon attenuation and contributions from scattered photons reduce the accuracy of measured activities and activity concentrations. In addition, limited spatial resolution causes a “hot” object that is less than 2–3 times the system’s resolution in a “colder” background to appear blurred with reduced activity concentration (partial volume effect). While the total reconstructed counts within the object are conserved, the count density is decreased from the true value because the data are distributed over a larger area than the object’s true activity distribution." @default.
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• W2029336121 title "Is absolute quantification of dopaminergic neurotransmission studies with 123I SPECT ready for clinical use?" @default.
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• W2029336121 doi "https://doi.org/10.1007/s00259-008-0842-x" @default.
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