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- W2029338338 abstract "The aldosterone-sensitive distal nephron (ASDN) includes the late distal convoluted tubule 2, the connecting tubule (CNT) and the collecting duct. The appropriate regulation of sodium (Na+) absorption in the ASDN is essential to precisely match urinary Na+ excretion to dietary Na+ intake whilst taking extra-renal Na+ losses into account. There is increasing evidence that Na+ transport in the CNT is of particular importance for the maintenance of body Na+ balance and for the long-term control of extra-cellular fluid volume and arterial blood pressure. Na+ transport in the CNT critically depends on the activity and abundance of the amiloride-sensitive epithelial sodium channel (ENaC) in the luminal membrane of the CNT cells. As a rate-limiting step for transepithelial Na+ transport, ENaC is the main target of hormones (e.g. aldosterone, angiotensin II, vasopressin and insulin/insulin-like growth factor 1) to adjust transepithelial Na+ transport in this tubular segment. In this review, we highlight the structural and functional properties of the CNT that contribute to the high Na+ transport capacity of this segment. Moreover, we discuss some aspects of the complex pathways and molecular mechanisms involved in ENaC regulation by hormones, kinases, proteases and associated proteins that control its function. Whilst cultured cells and heterologous expression systems have greatly advanced our knowledge about some of these regulatory mechanisms, future studies will have to determine the relative importance of the various pathways in the native tubule and in particular in the CNT." @default.
- W2029338338 created "2016-06-24" @default.
- W2029338338 creator A5031639542 @default.
- W2029338338 creator A5058284896 @default.
- W2029338338 date "2009-03-11" @default.
- W2029338338 modified "2023-10-18" @default.
- W2029338338 title "Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC)" @default.
- W2029338338 cites W1196491 @default.
- W2029338338 cites W1486524131 @default.
- W2029338338 cites W1505008375 @default.
- W2029338338 cites W1511127814 @default.
- W2029338338 cites W1535919368 @default.
- W2029338338 cites W1547589333 @default.
- W2029338338 cites W1566486303 @default.
- W2029338338 cites W1585031586 @default.
- W2029338338 cites W1585558973 @default.
- W2029338338 cites W1590547533 @default.
- W2029338338 cites W1674807282 @default.
- W2029338338 cites W1818300518 @default.
- W2029338338 cites W1820962178 @default.
- W2029338338 cites W1905022879 @default.
- W2029338338 cites W1906008749 @default.
- W2029338338 cites W1914869039 @default.
- W2029338338 cites W1960996609 @default.
- W2029338338 cites W1961777300 @default.
- W2029338338 cites W1964151355 @default.
- W2029338338 cites W1964217202 @default.
- W2029338338 cites W1964365041 @default.
- W2029338338 cites W1965038396 @default.
- W2029338338 cites W1965762453 @default.
- W2029338338 cites W1966102491 @default.
- W2029338338 cites W1966295792 @default.
- W2029338338 cites W1967005632 @default.
- W2029338338 cites W1968226795 @default.
- W2029338338 cites W1969898475 @default.
- W2029338338 cites W1971536987 @default.
- W2029338338 cites W1972543530 @default.
- W2029338338 cites W1974016431 @default.
- W2029338338 cites W1974043792 @default.
- W2029338338 cites W1975616172 @default.
- W2029338338 cites W1976125938 @default.
- W2029338338 cites W1976728586 @default.
- W2029338338 cites W1977518774 @default.
- W2029338338 cites W1977812691 @default.
- W2029338338 cites W1979112180 @default.
- W2029338338 cites W1979699722 @default.
- W2029338338 cites W1981315094 @default.
- W2029338338 cites W1981372032 @default.
- W2029338338 cites W1981631360 @default.
- W2029338338 cites W1981947859 @default.
- W2029338338 cites W1983430950 @default.
- W2029338338 cites W1985324468 @default.
- W2029338338 cites W1985567618 @default.
- W2029338338 cites W1987781885 @default.
- W2029338338 cites W1988101098 @default.
- W2029338338 cites W1989009278 @default.
- W2029338338 cites W1991264283 @default.
- W2029338338 cites W1991669847 @default.
- W2029338338 cites W1992495580 @default.
- W2029338338 cites W1992847420 @default.
- W2029338338 cites W1993835711 @default.
- W2029338338 cites W1994304837 @default.
- W2029338338 cites W1994562335 @default.
- W2029338338 cites W1995294810 @default.
- W2029338338 cites W1995607268 @default.
- W2029338338 cites W1995994950 @default.
- W2029338338 cites W1998751393 @default.
- W2029338338 cites W1999274244 @default.
- W2029338338 cites W2000379309 @default.
- W2029338338 cites W2002563649 @default.
- W2029338338 cites W2003625263 @default.
- W2029338338 cites W2004049927 @default.
- W2029338338 cites W2004970918 @default.
- W2029338338 cites W2005579207 @default.
- W2029338338 cites W2006363853 @default.
- W2029338338 cites W2008806257 @default.
- W2029338338 cites W2009651486 @default.
- W2029338338 cites W2009665317 @default.
- W2029338338 cites W2010733391 @default.
- W2029338338 cites W2011427196 @default.
- W2029338338 cites W2013711061 @default.
- W2029338338 cites W2013817923 @default.
- W2029338338 cites W2014968021 @default.
- W2029338338 cites W2015345138 @default.
- W2029338338 cites W2016911926 @default.
- W2029338338 cites W2017766022 @default.
- W2029338338 cites W2017783236 @default.
- W2029338338 cites W2017944747 @default.
- W2029338338 cites W2018796635 @default.
- W2029338338 cites W2018978933 @default.
- W2029338338 cites W2019099644 @default.
- W2029338338 cites W2020056111 @default.
- W2029338338 cites W2020620553 @default.
- W2029338338 cites W2022941489 @default.
- W2029338338 cites W2023479492 @default.
- W2029338338 cites W2024504227 @default.
- W2029338338 cites W2024594717 @default.
- W2029338338 cites W2028053979 @default.