FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029341502> ?p ?o ?g. }

• W2029341502 endingPage "300" @default.
• W2029341502 startingPage "292" @default.
• W2029341502 abstract "Prostate cancer (PCa) harbors a myriad of genomic and epigenetic defects. Cytosine methylation of CpG-rich promoter DNA is an important mechanism of epigenetic gene inactivation in PCa. There is considerable amount of data to suggest that DNA methylation-based biomarkers may be useful for the early detection and diagnosis of PCa. In addition, candidate gene-based studies have shown an association between specific gene methylation and alterations and clinicopathologic indicators of poor prognosis in PCa. To more comprehensively identify DNA methylation alterations in PCa initiation and progression, we examined the methylation status of 485 577 CpG sites from regions with a broad spectrum of CpG densities, interrogating both gene-associated and non-associated regions using the recently developed Illumina 450K methylation platform. In all, we selected 33 promoter-associated novel CpG sites that were differentially methylated in high-grade prostatic intraepithelial neoplasia and PCa in comparison with benign prostate tissue samples (false discovery rate-adjusted P-value <0.05; β-value ⩾0.2; fold change >1.5). Of the 33 genes, hierarchical clustering analysis demonstrated BNC1, FZD1, RPL39L, SYN2, LMX1B, CXXC5, ZNF783 and CYB5R2 as top candidate novel genes that are frequently methylated and whose methylation was associated with inactivation of gene expression in PCa cell lines. Pathway analysis of the genes with altered methylation patterns identified the involvement of a cancer-related network of genes whose activity may be regulated by TP53, MYC, TNF, IL1 and 6, IFN-γ and FOS in prostate pathogenesis. Our genome-wide methylation profile shows epigenetic dysregulation of important regulatory signals in prostate carcinogenesis." @default.
• W2029341502 created "2016-06-24" @default.
• W2029341502 creator A5004765876 @default.
• W2029341502 creator A5044300649 @default.
• W2029341502 creator A5044406987 @default.
• W2029341502 creator A5044449677 @default.
• W2029341502 creator A5055284245 @default.
• W2029341502 creator A5066263660 @default.
• W2029341502 creator A5075947272 @default.
• W2029341502 creator A5082689292 @default.
• W2029341502 creator A5089860022 @default.
• W2029341502 date "2013-07-30" @default.
• W2029341502 modified "2023-10-11" @default.
• W2029341502 title "Identification of novel DNA-methylated genes that correlate with human prostate cancer and high-grade prostatic intraepithelial neoplasia" @default.
• W2029341502 cites W1484293540 @default.
• W2029341502 cites W1486257535 @default.
• W2029341502 cites W1493975626 @default.
• W2029341502 cites W1504303645 @default.
• W2029341502 cites W1580316843 @default.
• W2029341502 cites W159258049 @default.
• W2029341502 cites W1637312052 @default.
• W2029341502 cites W1967064280 @default.
• W2029341502 cites W1974747095 @default.
• W2029341502 cites W1990236447 @default.
• W2029341502 cites W1994229067 @default.
• W2029341502 cites W2004486672 @default.
• W2029341502 cites W2007521294 @default.
• W2029341502 cites W2012699762 @default.
• W2029341502 cites W2014852291 @default.
• W2029341502 cites W2016617960 @default.
• W2029341502 cites W2021349467 @default.
• W2029341502 cites W2026431475 @default.
• W2029341502 cites W2028934624 @default.
• W2029341502 cites W2040257851 @default.
• W2029341502 cites W2045316197 @default.
• W2029341502 cites W2052140659 @default.
• W2029341502 cites W2053093486 @default.
• W2029341502 cites W2053102671 @default.
• W2029341502 cites W2056040742 @default.
• W2029341502 cites W2070166913 @default.
• W2029341502 cites W2073227325 @default.
• W2029341502 cites W2074746593 @default.
• W2029341502 cites W2076809631 @default.
• W2029341502 cites W2084748297 @default.
• W2029341502 cites W2096107919 @default.
• W2029341502 cites W2103714979 @default.
• W2029341502 cites W2121417064 @default.
• W2029341502 cites W2122669251 @default.
• W2029341502 cites W2123978931 @default.
• W2029341502 cites W2126260598 @default.
• W2029341502 cites W2126689461 @default.
• W2029341502 cites W2132778659 @default.
• W2029341502 cites W2133918562 @default.
• W2029341502 cites W2137082708 @default.
• W2029341502 cites W2139031446 @default.
• W2029341502 cites W2141410747 @default.
• W2029341502 cites W2145455405 @default.
• W2029341502 cites W2145750252 @default.
• W2029341502 cites W2149023124 @default.
• W2029341502 cites W2154087715 @default.
• W2029341502 cites W2160704282 @default.
• W2029341502 cites W2161988535 @default.
• W2029341502 cites W2171118724 @default.
• W2029341502 cites W2171788646 @default.
• W2029341502 cites W2329888282 @default.
• W2029341502 doi "https://doi.org/10.1038/pcan.2013.21" @default.
• W2029341502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23896626" @default.
• W2029341502 hasPublicationYear "2013" @default.
• W2029341502 type Work @default.
• W2029341502 sameAs 2029341502 @default.
• W2029341502 citedByCount "47" @default.
• W2029341502 countsByYear W20293415022014 @default.
• W2029341502 countsByYear W20293415022015 @default.
• W2029341502 countsByYear W20293415022016 @default.
• W2029341502 countsByYear W20293415022017 @default.
• W2029341502 countsByYear W20293415022018 @default.
• W2029341502 countsByYear W20293415022019 @default.
• W2029341502 countsByYear W20293415022020 @default.
• W2029341502 countsByYear W20293415022021 @default.
• W2029341502 countsByYear W20293415022022 @default.
• W2029341502 countsByYear W20293415022023 @default.
• W2029341502 crossrefType "journal-article" @default.
• W2029341502 hasAuthorship W2029341502A5004765876 @default.
• W2029341502 hasAuthorship W2029341502A5044300649 @default.
• W2029341502 hasAuthorship W2029341502A5044406987 @default.
• W2029341502 hasAuthorship W2029341502A5044449677 @default.
• W2029341502 hasAuthorship W2029341502A5055284245 @default.
• W2029341502 hasAuthorship W2029341502A5066263660 @default.
• W2029341502 hasAuthorship W2029341502A5075947272 @default.
• W2029341502 hasAuthorship W2029341502A5082689292 @default.
• W2029341502 hasAuthorship W2029341502A5089860022 @default.
• W2029341502 hasBestOaLocation W20293415021 @default.
• W2029341502 hasConcept C104317684 @default.
• W2029341502 hasConcept C121608353 @default.
• W2029341502 hasConcept C136953436 @default.
• W2029341502 hasConcept C140173407 @default.
• W2029341502 hasConcept C150194340 @default.
• W2029341502 hasConcept C154253233 @default.

• next