FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029350780> ?p ?o ?g. }

• W2029350780 endingPage "1875" @default.
• W2029350780 startingPage "1869" @default.
• W2029350780 abstract "The present study describes a follow-up of a prospective and observational cohort of patients infected with HIV-1 and treated with raltegravir for salvage therapy in Brazil. Two groups of patients were analyzed: switching from T20 to RAL (Group 1, n = 9) and salvage therapy containing RAL (Group 2, n = 10). Blood samples were drawn for CD4+ T-cell counts and HIV-1 viral load determinations. Protease, reverse transcriptase, and integrase genotyping were performed at baseline and at the time of virologic failure. CD4+ T-cells increased at 6 and 12 months in both groups; HIV-1 viral load was continuously suppressed for Group 1, and for Group 2 it significantly decreased after starting a RAL-containing regimen. Three out of 10 patients from Group 2 could not suppress HIV-1 viral load. The mutations Q148H + G140S were observed for two patients and for the third patient only mutations to PR/RT inhibitors were detected. The genotypic sensitivity score (GSS) was analyzed for all patients of Group 2 and both patients who developed resistance to raltegravir presented a GSS < 2.0 for the RAL-containing scheme, which could be associated to the lack of effectiveness of the proposed scheme. The present study describes, for the first time in Brazil, the close follow-up of a series of patients using a raltegravir-containing HAART, showing the safety of the enfuvirtide switch to RAL and the effectiveness of a therapeutic regimen with RAL in promoting immune reconstitution and suppressing HIV replication, as well as documenting the occurrence of resistance to integrase inhibitors in the country. J. Med. Virol. 84:1869–1875, 2012. © 2012 Wiley Periodicals, Inc." @default.
• W2029350780 created "2016-06-24" @default.
• W2029350780 creator A5011463781 @default.
• W2029350780 creator A5024931884 @default.
• W2029350780 creator A5046808969 @default.
• W2029350780 creator A5064988210 @default.
• W2029350780 creator A5070719160 @default.
• W2029350780 creator A5084897358 @default.
• W2029350780 creator A5087601006 @default.
• W2029350780 date "2012-10-10" @default.
• W2029350780 modified "2023-09-27" @default.
• W2029350780 title "Monitoring the emergence of resistance mutations in patients infected with HIV-1 under salvage therapy with raltegravir in Rio de Janeiro, Brazil: A follow-up study" @default.
• W2029350780 cites W1973261539 @default.
• W2029350780 cites W1983837630 @default.
• W2029350780 cites W1988062692 @default.
• W2029350780 cites W1994342377 @default.
• W2029350780 cites W1994770156 @default.
• W2029350780 cites W1999924359 @default.
• W2029350780 cites W2005141763 @default.
• W2029350780 cites W2015961470 @default.
• W2029350780 cites W2023101804 @default.
• W2029350780 cites W2027462483 @default.
• W2029350780 cites W2028694978 @default.
• W2029350780 cites W2032800042 @default.
• W2029350780 cites W2040557088 @default.
• W2029350780 cites W2041921162 @default.
• W2029350780 cites W2043485148 @default.
• W2029350780 cites W2046412323 @default.
• W2029350780 cites W2050943416 @default.
• W2029350780 cites W2053125329 @default.
• W2029350780 cites W2056182928 @default.
• W2029350780 cites W2058181494 @default.
• W2029350780 cites W2063481480 @default.
• W2029350780 cites W2072518790 @default.
• W2029350780 cites W2084536469 @default.
• W2029350780 cites W2087445857 @default.
• W2029350780 cites W2090070116 @default.
• W2029350780 cites W2095361185 @default.
• W2029350780 cites W2095751322 @default.
• W2029350780 cites W2099024192 @default.
• W2029350780 cites W2104937944 @default.
• W2029350780 cites W2114822477 @default.
• W2029350780 cites W2132720747 @default.
• W2029350780 cites W2133024144 @default.
• W2029350780 cites W2133362267 @default.
• W2029350780 cites W2135417699 @default.
• W2029350780 cites W2137646827 @default.
• W2029350780 cites W2139960736 @default.
• W2029350780 cites W2150504993 @default.
• W2029350780 cites W2152803777 @default.
• W2029350780 cites W2157887699 @default.
• W2029350780 cites W2158159244 @default.
• W2029350780 cites W2161993838 @default.
• W2029350780 cites W2164541113 @default.
• W2029350780 doi "https://doi.org/10.1002/jmv.23409" @default.
• W2029350780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23080489" @default.
• W2029350780 hasPublicationYear "2012" @default.
• W2029350780 type Work @default.
• W2029350780 sameAs 2029350780 @default.
• W2029350780 citedByCount "1" @default.
• W2029350780 countsByYear W20293507802014 @default.
• W2029350780 crossrefType "journal-article" @default.
• W2029350780 hasAuthorship W2029350780A5011463781 @default.
• W2029350780 hasAuthorship W2029350780A5024931884 @default.
• W2029350780 hasAuthorship W2029350780A5046808969 @default.
• W2029350780 hasAuthorship W2029350780A5064988210 @default.
• W2029350780 hasAuthorship W2029350780A5070719160 @default.
• W2029350780 hasAuthorship W2029350780A5084897358 @default.
• W2029350780 hasAuthorship W2029350780A5087601006 @default.
• W2029350780 hasConcept C104317684 @default.
• W2029350780 hasConcept C126322002 @default.
• W2029350780 hasConcept C135763542 @default.
• W2029350780 hasConcept C142462285 @default.
• W2029350780 hasConcept C14430832 @default.
• W2029350780 hasConcept C147483822 @default.
• W2029350780 hasConcept C156719811 @default.
• W2029350780 hasConcept C159047783 @default.
• W2029350780 hasConcept C195616568 @default.
• W2029350780 hasConcept C203014093 @default.
• W2029350780 hasConcept C2776258796 @default.
• W2029350780 hasConcept C2776694085 @default.
• W2029350780 hasConcept C2777302000 @default.
• W2029350780 hasConcept C2778037500 @default.
• W2029350780 hasConcept C2778899366 @default.
• W2029350780 hasConcept C2780404665 @default.
• W2029350780 hasConcept C2780775027 @default.
• W2029350780 hasConcept C2781413609 @default.
• W2029350780 hasConcept C2993143319 @default.
• W2029350780 hasConcept C3013748606 @default.
• W2029350780 hasConcept C31467283 @default.
• W2029350780 hasConcept C49105822 @default.
• W2029350780 hasConcept C55493867 @default.
• W2029350780 hasConcept C71924100 @default.
• W2029350780 hasConcept C86803240 @default.
• W2029350780 hasConceptScore W2029350780C104317684 @default.
• W2029350780 hasConceptScore W2029350780C126322002 @default.
• W2029350780 hasConceptScore W2029350780C135763542 @default.
• W2029350780 hasConceptScore W2029350780C142462285 @default.

• next