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• W2029351439 abstract "Abstract The management of systemic lupus erythematosus (SLE) has improved in the past 50 years, but there is still a 3–5‐fold increased mortality compared to the general population, with major organ failure due to active disease, infection and cardiovascular disease as the major challenges for the coming decade. Research advances at cellular, molecular and genetic levels enhance our understanding of the immunopathogenic mechanisms of SLE, leading to the development of drugs targeting specific sites of immune dysregulation – with therapies directed at cytokines, B‐ and T‐cells, and their interactions showing promise. Advances are expected in the field of haematopoietic stem cell transplant (HSCT) as a therapeutic option for a subset of patients. Furthermore, some non‐traditional immunomodulating therapies like statins, leflunomide and tacrolimus may prove useful as alternative or adjunct treatment in some patients. A better understanding of how current immunosuppressants act at the cellular and molecular level should guide the re‐evaluation of the indications, doses and duration of therapy in clinical trials using these agents, many of which have not been subjected to proper double‐blinded placebo‐controlled studies. Research on triggers of SLE onset and flare of activity continues to yield information helpful in prevention. The evidence on the impact of psychosocial and economic factors on the outcome of SLE is overwhelming and the rheumatology community should enlist the assistance of other healthcare professionals, patient advocates and local health authorities to address these issues pertinent to good patient care and outcome." @default.
• W2029351439 created "2016-06-24" @default.
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• W2029351439 date "2006-11-10" @default.
• W2029351439 modified "2023-10-16" @default.
• W2029351439 title "Management of systemic lupus erythematosus in the coming decade: potentials and challenges" @default.
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• W2029351439 doi "https://doi.org/10.1111/j.1479-8077.2006.00244.x" @default.
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