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- W2029360391 abstract "Background Antibodies against proinflammatory phosphorylcholine (anti-PC) seem to be protective and reduce morbidity. We sought to determine whether low levels of immunoglobulin-M (IgM) autoantibodies against PC add prognostic information in acute coronary syndromes (ACS). Methods IgM anti-PC titers were measured in serum obtained within 24 h of admission from 1185 ACS patients (median age 66 years, 30% women). We evaluated major acute cardiovascular events (MACE) and all-cause mortality short- (6 months), intermediate- (18 months) and long- (72 months) terms. Results Low anti-PC titers were associated with MACE and all-cause mortality at all follow-up times. After adjusting for clinical variables, plasma troponin-I, proBNP and CRP levels, associations remained at all times with MACE, short and intermediate terms also with all-cause mortality. With anti-PC titers below median, adjusted hazard ratios at 18 months were for MACE 1.79 (95% confidence interval [CI]: 1.31 to 2.44; p=0.0002) and for all-cause mortality 2.28 (95% CI: 1.32 to 3.92; p=0.003). Anti-PC and plasma CRP were unrelated and added to risk prediction. Conclusions Serum IgM anti-PC titers provide prognostic information above traditional risk factors in ACS. The ease of measurement and potential therapeutic perspective indicate that it may be a valuable novel biomarker in ACS." @default.
- W2029360391 created "2016-06-24" @default.
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- W2029360391 date "2013-07-01" @default.
- W2029360391 modified "2023-10-17" @default.
- W2029360391 title "IgM-phosphorylcholine autoantibodies and outcome in acute coronary syndromes" @default.
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- W2029360391 doi "https://doi.org/10.1016/j.ijcard.2012.01.018" @default.
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