FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029362415> ?p ?o ?g. }

• W2029362415 endingPage "1403" @default.
• W2029362415 startingPage "1395" @default.
• W2029362415 abstract "The pathophysiology of major depressive disorder (MDD) includes both affective and cognitive dysfunctions. We aimed to clarify how regions regulating affective processing interact with those involved in attention, and how such interaction impacts perceptual processing within sensory cortices. Based on previous work showing that top-down influences from attention can determine the processing of external inputs within early sensory cortices, we tested with functional magnetic resonance imaging (fMRI) whether MDD alters attentional (“top-down”) effects on the neural filtering of irrelevant, nonemotional visual stimuli. The present fMRI study was conducted in 14 nonmedicated patients with a first episode of unipolar MDD and 14 matched controls. During scanning, subjects performed two tasks imposing two different levels of attentional load at fixation (easy or difficult), while irrelevant colored stimuli were presented in the periphery. Analyses of fMRI data revealed that MDD patients show (1) an abnormal filtering of irrelevant information in visual cortex, (2) an altered functional connectivity between frontoparietal networks and visual cortices, and (3) a hyperactivity in subgenual cingulate/medial orbitofrontal cortex that was modulated by attentional load. These results demonstrate that biological abnormalities contribute to the cognitive deficits seen in major depression, and clarify how neural networks implicated in mood regulation influence executive control and perceptual processes. These findings not only improve our understanding of the pathophysiological mechanisms underlying cognitive dysfunctions in MDD, but also shed new light on the interaction between cognition and mood regulation." @default.
• W2029362415 created "2016-06-24" @default.
• W2029362415 creator A5004542274 @default.
• W2029362415 creator A5005472608 @default.
• W2029362415 creator A5012386206 @default.
• W2029362415 creator A5018470387 @default.
• W2029362415 creator A5018625388 @default.
• W2029362415 creator A5018865784 @default.
• W2029362415 creator A5019430989 @default.
• W2029362415 creator A5024356048 @default.
• W2029362415 creator A5039177178 @default.
• W2029362415 creator A5049301968 @default.
• W2029362415 creator A5053619356 @default.
• W2029362415 creator A5054096836 @default.
• W2029362415 creator A5064657873 @default.
• W2029362415 creator A5066489976 @default.
• W2029362415 creator A5083379298 @default.
• W2029362415 creator A5083658031 @default.
• W2029362415 creator A5087211088 @default.
• W2029362415 creator A5089232791 @default.
• W2029362415 date "2009-02-04" @default.
• W2029362415 modified "2023-10-15" @default.
• W2029362415 title "Abnormal Neural Filtering of Irrelevant Visual Information in Depression" @default.
• W2029362415 cites W1578804663 @default.
• W2029362415 cites W1665095741 @default.
• W2029362415 cites W1967104219 @default.
• W2029362415 cites W1969556630 @default.
• W2029362415 cites W1970242526 @default.
• W2029362415 cites W1974244275 @default.
• W2029362415 cites W1986429531 @default.
• W2029362415 cites W1991880588 @default.
• W2029362415 cites W1997245512 @default.
• W2029362415 cites W1998407084 @default.
• W2029362415 cites W2006091191 @default.
• W2029362415 cites W2010752391 @default.
• W2029362415 cites W2032677613 @default.
• W2029362415 cites W2036970657 @default.
• W2029362415 cites W2047104613 @default.
• W2029362415 cites W2053472601 @default.
• W2029362415 cites W2055210002 @default.
• W2029362415 cites W2076972670 @default.
• W2029362415 cites W2084668768 @default.
• W2029362415 cites W2084721650 @default.
• W2029362415 cites W2095438393 @default.
• W2029362415 cites W2100991928 @default.
• W2029362415 cites W2102613472 @default.
• W2029362415 cites W2104393125 @default.
• W2029362415 cites W2105119061 @default.
• W2029362415 cites W2105389170 @default.
• W2029362415 cites W2114613490 @default.
• W2029362415 cites W2116945806 @default.
• W2029362415 cites W2117207767 @default.
• W2029362415 cites W2120471995 @default.
• W2029362415 cites W2120724038 @default.
• W2029362415 cites W2121056041 @default.
• W2029362415 cites W2121075052 @default.
• W2029362415 cites W2125917054 @default.
• W2029362415 cites W2127765363 @default.
• W2029362415 cites W2132838344 @default.
• W2029362415 cites W2133780491 @default.
• W2029362415 cites W2140344971 @default.
• W2029362415 cites W2140583928 @default.
• W2029362415 cites W2141460037 @default.
• W2029362415 cites W2143380734 @default.
• W2029362415 cites W2144351977 @default.
• W2029362415 cites W2144538553 @default.
• W2029362415 cites W2150215146 @default.
• W2029362415 cites W2150407416 @default.
• W2029362415 cites W2151041365 @default.
• W2029362415 cites W2154117736 @default.
• W2029362415 cites W2156761163 @default.
• W2029362415 cites W2157217643 @default.
• W2029362415 cites W2158718741 @default.
• W2029362415 cites W2161710337 @default.
• W2029362415 cites W2322340007 @default.
• W2029362415 cites W2777987555 @default.
• W2029362415 cites W2889622349 @default.
• W2029362415 cites W4232610642 @default.
• W2029362415 cites W4233058775 @default.
• W2029362415 doi "https://doi.org/10.1523/jneurosci.3341-08.2009" @default.
• W2029362415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6666064" @default.
• W2029362415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19193886" @default.
• W2029362415 hasPublicationYear "2009" @default.
• W2029362415 type Work @default.
• W2029362415 sameAs 2029362415 @default.
• W2029362415 citedByCount "100" @default.
• W2029362415 countsByYear W20293624152012 @default.
• W2029362415 countsByYear W20293624152013 @default.
• W2029362415 countsByYear W20293624152014 @default.
• W2029362415 countsByYear W20293624152015 @default.
• W2029362415 countsByYear W20293624152016 @default.
• W2029362415 countsByYear W20293624152017 @default.
• W2029362415 countsByYear W20293624152018 @default.
• W2029362415 countsByYear W20293624152019 @default.
• W2029362415 countsByYear W20293624152020 @default.
• W2029362415 countsByYear W20293624152021 @default.
• W2029362415 countsByYear W20293624152022 @default.
• W2029362415 countsByYear W20293624152023 @default.

• next