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- W2029366229 abstract "To test the hypothesis that insulin receptors may be modulated by metabolic events within the target cells, we investigated the relation between lipolysis and insulin binding in isolated fat cells of the rat. The stimulation of lipolysis by theophylline was associated with a significant decrease of insulin binding. The concentration-response curves suggested a close correlation of both effects of theophylline. Binding curves revealed a decrease of the affinity rather than a reduction of the number of insulin receptors. Methylpyrazolecarboxylic acid, an antilipolytic agent, antagonized the effects of theophylline on both lipolysis and insulin binding." @default.
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- W2029366229 date "1982-01-01" @default.
- W2029366229 modified "2023-09-25" @default.
- W2029366229 title "In vitro effects of theophylline on insulin receptors in adipocytes: Correlation with the lipolytic action of the agent" @default.
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- W2029366229 doi "https://doi.org/10.1016/0006-291x(82)91938-6" @default.
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