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• W2029372019 abstract "Listeria monocytogenes causes a pro-inflammatory response on adhesion to macrophages. Upregulation of inflammation genes involves the transcription factor NF-κB. Several components of L. monocytogenes, including lipoteichoic acid (LTA), phospholipases and listeriolysin O (LLO), have since been shown to mediate NF-κB activation. Here, we report that purified recombinant InlB, but not internalin (InlA), is a potent activator of NF-κB in the mouse macrophage-like cell line J774. Expression of InlB in Listeria innocua enhances its ability to activate NF-κB, while deletion of InlB from L. monocytogenes marginally decreases its effect on NF-κB, possibly because of the presence of NF-κB activators such as LTA and LLO. The effect correlates with the rapid degradation of IκBα, a sustained degradation of IκBβ and increases in tumour necrosis factor alpha (TNF-α) and interleukin (IL) 6 production, two cytokines controlled by NF-κB. Using a series of anti-InlB monoclonal antibodies and domains of InlB, NF-κB activation was shown to be dependent upon the N-terminal 213-amino-acid leucine-rich repeat (LRR) domain of InlB, recently demonstrated to be responsible for InlB-mediated L. monocytogenes invasion and phosphoinositide-3 (PI-3) kinase activation. The effect of InlB was blocked by PI-3 kinase inhibitors, indicating the involvement of PI-3 kinase in this response. This report thus illustrates that InlB not only promotes invasion, but also contributes to the macrophage pro-inflammatory response." @default.
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• W2029372019 date "2000-04-01" @default.
• W2029372019 modified "2023-09-25" @default.
• W2029372019 title "A novel function of InlB from Listeria monocytogenes: activation of NF-kappaB in J774 macrophages" @default.
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• W2029372019 doi "https://doi.org/10.1046/j.1462-5822.2000.00038.x" @default.
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