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- W2029372225 abstract "Recent studies have revealed the presence of a microtubule subpopulation called Golgi-derived microtubules that support Golgi ribbon formation, which is required for maintaining polarized cell migration. CLASPs and AKAP450/CG-NAP are involved in their formation, but the underlying molecular mechanisms remain unclear. Here, we find that the microtubule-crosslinking protein, MTCL1, is recruited to the Golgi membranes through interactions with CLASPs and AKAP450/CG-NAP, and promotes microtubule growth from the Golgi membrane. Correspondingly, MTCL1 knockdown specifically impairs the formation of the stable perinuclear microtubule network to which the Golgi ribbon tethers and extends. Rescue experiments demonstrate that besides its crosslinking activity mediated by the N-terminal microtubule-binding region, the C-terminal microtubule-binding region plays essential roles in these MTCL1 functions through a novel microtubule-stabilizing activity. These results suggest that MTCL1 cooperates with CLASPs and AKAP450/CG-NAP in the formation of the Golgi-derived microtubules, and mediates their development into a stable microtubule network. Microtubules that nucleate from the surface of the Golgi network are important for polarized trafficking and cell migration. Sato et al.find that these microtubules are crosslinked and stabilized by the microtubule-binding protein MTCL1, and show that this activity is required for Golgi structure and function." @default.
- W2029372225 created "2016-06-24" @default.
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- W2029372225 date "2014-11-04" @default.
- W2029372225 modified "2023-10-03" @default.
- W2029372225 title "MTCL1 crosslinks and stabilizes non-centrosomal microtubules on the Golgi membrane" @default.
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- W2029372225 doi "https://doi.org/10.1038/ncomms6266" @default.
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