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- W2029376677 abstract "The completion of independent searches for genes that influence susceptibility to multiple sclerosis (MS), the common autoimmune demyelinating disease of young adults, has been announced in a trio of research papers. 1 Sawcer S Jones HB Feakes R et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet. 1996; 13: 464-468 Crossref PubMed Scopus (590) Google Scholar , 2 The Multiple Sclerosis Genetics Group A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nat Genet. 1996; 13: 469-471 Crossref PubMed Scopus (614) Google Scholar , 3 Ebers GC Kukay K Bulman DE et al. A full genome search in multiple sclerosis. Nat Genet. 1996; 13: 472-476 Crossref PubMed Scopus (612) Google Scholar From a genetic epidemiologist's perspective, MS adheres closely to a multifactorial model of pathogenesis in which several discrete inherited and environmental factors interact. The importance of the contribution of genes is reflected in estimates of the risk ratio (RR) that range from 20 to 50 for siblings of MS patients compared with the population prevalence. 4 Sadovnick AD Baird PA Ward RH Multiple sclerosis: updated risks for relatives. Am J Med Genet. 1988; 29: 533-541 Crossref PubMed Scopus (262) Google Scholar , 5 Robertson NP Fraser M Deans J Clayton D Compston DAS Age adjusted recurrence risks for relatives of patients with multiple sclerosis. Brain. 1996; 119: 449-455 Crossref PubMed Scopus (184) Google Scholar Given this striking degree of familial clustering (the RR for type 1 diabetes, for instance, is 15), the motivation systematically to screen the genome for individual susceptibility genes is sound, with the prospect that future positional cloning strategies would generate insights into the largely unknown causes of this devastating disease." @default.
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- W2029376677 title "Mapping genetic susceptibility to multiple sclerosis" @default.
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- W2029376677 doi "https://doi.org/10.1016/s0140-6736(05)65817-5" @default.
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