Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029377908> ?p ?o ?g. }
- W2029377908 endingPage "5614" @default.
- W2029377908 startingPage "5609" @default.
- W2029377908 abstract "Abstract Paradigm shifting advances in cancer can occur after discovering the key oncogenic drivers of the malignant process, understanding their detailed molecular mechanisms, and exploiting this transdisciplinary knowledge therapeutically. A variety of human malignancies have anaplastic lymphoma kinase (ALK) translocations, amplifications, or oncogenic mutations, including anaplastic large cell lymphoma, inflammatory myofibroblastic tumors, non–small cell lung cancer, and neuroblastoma. This finding has focused intense interest in inhibiting ALK signaling as an effective molecular therapy against diseases with ALK-driven pathways. Recent progress in the elucidation of the major canonical signaling pathways postulated to be activated by NPM-ALK signaling has provided insight into which pathways may present a rational therapeutic approach. The identification of the downstream effector pathways controlled by ALK should pave the way for the rational design of ALK-inhibition therapies for the treatment of a subset of human cancers that harbor ALK aberrations. (Clin Cancer Res 2009;15(18):5609–14)" @default.
- W2029377908 created "2016-06-24" @default.
- W2029377908 creator A5005797590 @default.
- W2029377908 creator A5030496565 @default.
- W2029377908 creator A5075837989 @default.
- W2029377908 date "2009-09-14" @default.
- W2029377908 modified "2023-10-12" @default.
- W2029377908 title "Inhibition of ALK Signaling for Cancer Therapy" @default.
- W2029377908 cites W1485721926 @default.
- W2029377908 cites W1517005017 @default.
- W2029377908 cites W1528343569 @default.
- W2029377908 cites W1531048613 @default.
- W2029377908 cites W1639582946 @default.
- W2029377908 cites W1971828608 @default.
- W2029377908 cites W1975686452 @default.
- W2029377908 cites W1978144369 @default.
- W2029377908 cites W1981872831 @default.
- W2029377908 cites W1988757730 @default.
- W2029377908 cites W1992895077 @default.
- W2029377908 cites W1994438989 @default.
- W2029377908 cites W1998371249 @default.
- W2029377908 cites W1999416593 @default.
- W2029377908 cites W2007739717 @default.
- W2029377908 cites W2009742890 @default.
- W2029377908 cites W2010978319 @default.
- W2029377908 cites W2011937137 @default.
- W2029377908 cites W2014639631 @default.
- W2029377908 cites W2021452013 @default.
- W2029377908 cites W2022354436 @default.
- W2029377908 cites W2022789032 @default.
- W2029377908 cites W2026002143 @default.
- W2029377908 cites W2029218729 @default.
- W2029377908 cites W2031494655 @default.
- W2029377908 cites W2035282066 @default.
- W2029377908 cites W2035476809 @default.
- W2029377908 cites W2038053082 @default.
- W2029377908 cites W2038056960 @default.
- W2029377908 cites W2038586807 @default.
- W2029377908 cites W2041723408 @default.
- W2029377908 cites W2052578245 @default.
- W2029377908 cites W2055402151 @default.
- W2029377908 cites W2059425147 @default.
- W2029377908 cites W2060275730 @default.
- W2029377908 cites W2061278019 @default.
- W2029377908 cites W2075875937 @default.
- W2029377908 cites W2091639070 @default.
- W2029377908 cites W2099784353 @default.
- W2029377908 cites W2109770623 @default.
- W2029377908 cites W2123727052 @default.
- W2029377908 cites W2124478432 @default.
- W2029377908 cites W2127664810 @default.
- W2029377908 cites W2134607826 @default.
- W2029377908 cites W2136245178 @default.
- W2029377908 cites W2136549983 @default.
- W2029377908 cites W2140502641 @default.
- W2029377908 cites W2150424194 @default.
- W2029377908 cites W2150501295 @default.
- W2029377908 cites W2164784911 @default.
- W2029377908 cites W2168106545 @default.
- W2029377908 cites W2168691181 @default.
- W2029377908 cites W4211031423 @default.
- W2029377908 cites W4211075026 @default.
- W2029377908 cites W92570429 @default.
- W2029377908 doi "https://doi.org/10.1158/1078-0432.ccr-08-2762" @default.
- W2029377908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19737948" @default.
- W2029377908 hasPublicationYear "2009" @default.
- W2029377908 type Work @default.
- W2029377908 sameAs 2029377908 @default.
- W2029377908 citedByCount "154" @default.
- W2029377908 countsByYear W20293779082012 @default.
- W2029377908 countsByYear W20293779082013 @default.
- W2029377908 countsByYear W20293779082014 @default.
- W2029377908 countsByYear W20293779082015 @default.
- W2029377908 countsByYear W20293779082016 @default.
- W2029377908 countsByYear W20293779082017 @default.
- W2029377908 countsByYear W20293779082018 @default.
- W2029377908 countsByYear W20293779082019 @default.
- W2029377908 countsByYear W20293779082020 @default.
- W2029377908 countsByYear W20293779082021 @default.
- W2029377908 countsByYear W20293779082022 @default.
- W2029377908 countsByYear W20293779082023 @default.
- W2029377908 crossrefType "journal-article" @default.
- W2029377908 hasAuthorship W2029377908A5005797590 @default.
- W2029377908 hasAuthorship W2029377908A5030496565 @default.
- W2029377908 hasAuthorship W2029377908A5075837989 @default.
- W2029377908 hasBestOaLocation W20293779081 @default.
- W2029377908 hasConcept C117643217 @default.
- W2029377908 hasConcept C121608353 @default.
- W2029377908 hasConcept C143998085 @default.
- W2029377908 hasConcept C203014093 @default.
- W2029377908 hasConcept C2776232967 @default.
- W2029377908 hasConcept C2776256026 @default.
- W2029377908 hasConcept C2777872185 @default.
- W2029377908 hasConcept C2779338263 @default.
- W2029377908 hasConcept C502942594 @default.
- W2029377908 hasConcept C51785407 @default.
- W2029377908 hasConcept C54355233 @default.
- W2029377908 hasConcept C62478195 @default.