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- W2029378009 abstract "In order to further explore the utility of saliva cortisol as an accurate measure of adrenal steroid production, dexamethasone (DEX) and saline were administered intravenously at 0800h to eight normal male volunteers in a randomized design, and the effects on serum and saliva cortisol concentrations were measured at hourly intervals from 0800h–2300h. Saliva cortisol values were highly correlated to serum cortisol levels within-subjects under both conditions (r=0.78, p<0.025), however correlations were reduced in the DEX day sample pairs. Across-subject correlations at each time point were considerably more variable, reflecting interindividual differences in the saliva to serum cortisol ratios. No consistent time lag of saliva cortisol values in response to serum cortisol fluctuations was observed. These data suggest that saliva cortisol is an excellent index of changes in adrenal production of cortisol over time within individuals; however; it also suggests that salivary cortisol measures have less usefulness in comparing values across groups of individuals." @default.
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- W2029378009 date "1989-01-01" @default.
- W2029378009 modified "2023-10-11" @default.
- W2029378009 title "Saliva and serum cortisol dynamics following intravenous dexamethasone in normal volunteers" @default.
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- W2029378009 doi "https://doi.org/10.1016/0024-3205(89)90517-1" @default.
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