FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029380877> ?p ?o ?g. }

• W2029380877 endingPage "531" @default.
• W2029380877 startingPage "525" @default.
• W2029380877 abstract "<i>Aim</i>—To analyse the capacity for epithelial differentiation in synovial sarcoma using a new human cell line. <i>Methods</i>—A new human cell line, KU-SS-1, was established from a monophasic, spindle cell type of synovial sarcoma by grafting those cells on to severe combined immunodeficient (SCID) mice and then transferring them to in vitro culture systems. The KU-SS-1 cells were characterised by light and electron microscopy, and by immunohistochemical, flow cytometric, and cytogenetic analysis. <i>Results</i>—Primary tumour and cultured cells at passage 20 showed a positive reaction for vimentin, which is a mesenchymal marker. After 40 passages, subcultured cells were injected into SCID mice to induce further tumours. These advanced subcultured cells and the tumour cells that they induced were positive for cytokeratin, an epithelial marker, and exhibited epithelial ultrastructural features such as intermediate junctions. Furthermore, two colour immunofluorescent analysis for proliferating nuclear cell antigen (PCNA) and intermediate filaments showed that a large number of PCNA expressing cells were positive for vimentin, and that part of this fraction also expressed cytokeratin. The existence of cells with reactivity for these three markers indicated that, in this cell line, a fraction with high proliferating capacity had both mesenchymal and epithelial markers. In addition, cytogenetically, this cell line expressed the SYT–SSX chimaeric transcript as a result of the t(X;18)(p11;q11) translocation. <i>Conclusions</i>—A human synovial sarcoma cell line was established and stably maintained in cell culture for more than 70 passages. In addition, this cell line showed epithelial differentiation, which supports the hypothesis that synovial sarcoma is a carcinosarcoma like tumour with true epithelial differentiation. This cell line will be a useful tool for investigating the nature of this tumour and will contribute to clinical studies." @default.
• W2029380877 created "2016-06-24" @default.
• W2029380877 creator A5010772165 @default.
• W2029380877 creator A5030287679 @default.
• W2029380877 creator A5033571681 @default.
• W2029380877 creator A5066304083 @default.
• W2029380877 creator A5076886111 @default.
• W2029380877 creator A5078023756 @default.
• W2029380877 date "2000-07-01" @default.
• W2029380877 modified "2023-09-25" @default.
• W2029380877 title "Capacity for epithelial differentiation in synovial sarcoma: analysis of a new human cell line" @default.
• W2029380877 cites W1499892752 @default.
• W2029380877 cites W1544619917 @default.
• W2029380877 cites W1565915668 @default.
• W2029380877 cites W181242179 @default.
• W2029380877 cites W191912130 @default.
• W2029380877 cites W1944130357 @default.
• W2029380877 cites W1969559358 @default.
• W2029380877 cites W1977695551 @default.
• W2029380877 cites W1977813278 @default.
• W2029380877 cites W1979870208 @default.
• W2029380877 cites W1984813686 @default.
• W2029380877 cites W1989234844 @default.
• W2029380877 cites W1991318478 @default.
• W2029380877 cites W1993078782 @default.
• W2029380877 cites W1994896253 @default.
• W2029380877 cites W2003203193 @default.
• W2029380877 cites W2004935157 @default.
• W2029380877 cites W2009715243 @default.
• W2029380877 cites W2014809541 @default.
• W2029380877 cites W2016693266 @default.
• W2029380877 cites W2017046139 @default.
• W2029380877 cites W2017325023 @default.
• W2029380877 cites W2018725952 @default.
• W2029380877 cites W2019663874 @default.
• W2029380877 cites W2026060974 @default.
• W2029380877 cites W2027172528 @default.
• W2029380877 cites W2030569690 @default.
• W2029380877 cites W2034833980 @default.
• W2029380877 cites W2037134847 @default.
• W2029380877 cites W2038845041 @default.
• W2029380877 cites W2039136709 @default.
• W2029380877 cites W2040386268 @default.
• W2029380877 cites W2046345953 @default.
• W2029380877 cites W2046989749 @default.
• W2029380877 cites W2060101422 @default.
• W2029380877 cites W2060239142 @default.
• W2029380877 cites W2071758728 @default.
• W2029380877 cites W2073986526 @default.
• W2029380877 cites W2076209290 @default.
• W2029380877 cites W2085047575 @default.
• W2029380877 cites W2092399987 @default.
• W2029380877 cites W2096428903 @default.
• W2029380877 cites W2104842253 @default.
• W2029380877 cites W2116036125 @default.
• W2029380877 cites W2125977630 @default.
• W2029380877 cites W2406679883 @default.
• W2029380877 cites W2419293331 @default.
• W2029380877 cites W2422151218 @default.
• W2029380877 doi "https://doi.org/10.1136/jcp.53.7.525" @default.
• W2029380877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1731235" @default.
• W2029380877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10961176" @default.
• W2029380877 hasPublicationYear "2000" @default.
• W2029380877 type Work @default.
• W2029380877 sameAs 2029380877 @default.
• W2029380877 citedByCount "12" @default.
• W2029380877 countsByYear W20293808772023 @default.
• W2029380877 crossrefType "journal-article" @default.
• W2029380877 hasAuthorship W2029380877A5010772165 @default.
• W2029380877 hasAuthorship W2029380877A5030287679 @default.
• W2029380877 hasAuthorship W2029380877A5033571681 @default.
• W2029380877 hasAuthorship W2029380877A5066304083 @default.
• W2029380877 hasAuthorship W2029380877A5076886111 @default.
• W2029380877 hasAuthorship W2029380877A5078023756 @default.
• W2029380877 hasBestOaLocation W20293808771 @default.
• W2029380877 hasConcept C10205521 @default.
• W2029380877 hasConcept C104317684 @default.
• W2029380877 hasConcept C142669718 @default.
• W2029380877 hasConcept C142724271 @default.
• W2029380877 hasConcept C147447768 @default.
• W2029380877 hasConcept C148738053 @default.
• W2029380877 hasConcept C1491633281 @default.
• W2029380877 hasConcept C153911025 @default.
• W2029380877 hasConcept C198826908 @default.
• W2029380877 hasConcept C203014093 @default.
• W2029380877 hasConcept C204232928 @default.
• W2029380877 hasConcept C2776804306 @default.
• W2029380877 hasConcept C2776910622 @default.
• W2029380877 hasConcept C2778256501 @default.
• W2029380877 hasConcept C2779012181 @default.
• W2029380877 hasConcept C28328180 @default.
• W2029380877 hasConcept C34688535 @default.
• W2029380877 hasConcept C54355233 @default.
• W2029380877 hasConcept C55493867 @default.
• W2029380877 hasConcept C71924100 @default.
• W2029380877 hasConcept C78383274 @default.
• W2029380877 hasConcept C81885089 @default.
• W2029380877 hasConcept C86803240 @default.

• next