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• W2029384039 startingPage "716" @default.
• W2029384039 abstract "The purpose of this research was to test the hypothesis that insulin-like growth factor-I (IGF-I) regulates estradiol (E2) synthesis in human granulosa and granulosa luteal cells. Cells from individual follicles from spontaneous and human menopausal gonadotropin/CG-stimulated cycles were cultured in serum-free medium containing androstenedione, IGF-I, FSH, and/or CG. At 2, 4, and 6 days, E2 in the medium was measured by RIA. In the granulosa experiments, control cells produced basal levels of E2 at 2 days, and the levels increased with increasing follicle size. Treatment with FSH stimulated E2 production (on the average, 5-fold), and the effect was dose dependent (ED50 = 5 ng/mL or 16 mIU/mL). Incubation with IGF-I alone caused increases in E2 production comparable to those caused by FSH, and the IGF-I effect was dose dependent (ED50 = 8 ng/mL). In most cases, coincubation with FSH and IGF-I augmented E2 levels more than either hormone alone, and at 4 and 6 days the interaction was synergistic. The data from dose-response experiments suggested that the basis of the synergy between FSH and IGF-I was a marked potentiation by either hormone (approximately 10-fold) in the potency of the complementary hormone to stimulate E2 production. In the experiments with granulosa luteal cells from spontaneous and in vitro fertilization preovulatory follicles, the controls synthesized very high levels of E2 spontaneously at 2 days; however, E2 production declined 700% at 4 days, and no E2 was produced by control cells at 6 days. Treatment with FSH, CG, or IGF-I did not cause a significant increase in the high basal levels of E2 at 2 days. During subsequent culture, however, all three hormones stimulated E2 production at 4 and 6 days, but the increases were modest and not sustained. In contrast, coincubation of granulosa luteal cells with FSH plus IGF-I or CG plus IGF-I dramatically enhanced E2 production at 4 and 6 days (on the average, 4-fold), and the effects were sustained throughout the culture period. (ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2029384039 created "2016-06-24" @default.
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• W2029384039 date "1989-10-01" @default.
• W2029384039 modified "2023-10-18" @default.
• W2029384039 title "Insulin-Like Growth Factor-I Regulates Aromatase Activity in Human Granulosa and Granulosa Luteal Cells*" @default.
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• W2029384039 doi "https://doi.org/10.1210/jcem-69-4-716" @default.
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