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- W2029384516 abstract "Pavulon (Pancuronium Bromide), although has little effect on the circulatory system, not infrequently produces hypotension when administered to sick VLBW. We studied the glomerular filtration (GFR) by Inulin clearance and fractional sodium excretion (FeNa) in VLBW (n=5) in the first 3 days of life receiving Pavulon (0.1 mg/kg/dose) and compared the results with a similar group (n=11) not receiving Pavulon. None were hypotensive or in renal failure. The IV fluid, sodium infusion and thermal environment did not differ between groups. Inulin was given with a bolus of 50 to 100 mg/kg followed by infusion of 0.1 to 0.2 mg/kg/min. Timed urine and serum were collected and clearances calculated in standard fashion. The results (mean + s.d.) are as follows: There were no significant differences between groups on each day. Pavulon does not affect GFR or FeNa in sick VLBW infants. As a major portion of Pavulon is eliminated unchanged in urine, repeated administration in infants with renal failure may prolong its effect. (* indicates number of studies done on days 1,2, and 3.)" @default.
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- W2029384516 date "1985-04-01" @default.
- W2029384516 modified "2023-09-25" @default.
- W2029384516 title "1631 GLOMERULAR FILTRATION IN VERY LOW BIRTH WEIGHT (VLBW) INFANTS TREATED WITH NEUROMUSCULAR BLOCKING AGENT" @default.
- W2029384516 doi "https://doi.org/10.1203/00006450-198504000-01655" @default.
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