FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029384872> ?p ?o ?g. }

• W2029384872 abstract "We have recently demonstrated that treatment of pregnant baboons with androstenedione (delta 4 A) at midgestation to increase estrogen production induced a pattern of placental cortisol (F) metabolism which was similar to that at term and resulted in de novo F production by the fetus, presumably by activation of the fetal hypothalamic-pituitary-adrenocortical axis. The present study was designed to examine the subcellular events in the fetal adrenal that were apparently stimulated by estrogen-induced alterations in transplacental corticosteroid metabolism. Therefore, we determined the effects of estrogen treatment at midgestation and removal of estrogen action near term on the specific activity of the rate-limiting enzymes delta 5-3 beta-hydroxysteroid dehydrogenase (3 beta HSD) and 17-hydroxylase-17,20-lyase (17 alpha-OHase). Fetal adrenals were obtained on day 100 (n = 11) or day 165 (n = 11) of gestation (term = day 184) from untreated animals, on day 100 from animals receiving delta 4 A daily between days 70-100 (n = 9) to increase placental estrogen production, and on day 165 from baboons treated daily between days 130-164 with antiestrogen ethamoxytriphetol (MER-25; n = 7). The activity of 17 alpha-OHase was determined by incubating adrenal microsomes (105,000 x g) with [3H] progesterone, NAD+, and NADH in phosphate buffer. The radiolabeled products 17-hydroxyprogesterone, delta 4 A, and testosterone were purified, and enzyme activity expressed as picograms of product per min/mg tissue. The activity of 3 beta HSD was determined by incubating adrenal microsomes with [3H]pregnenolone and NAD+ in phosphate buffer. The radiolabeled progesterone product was purified, and enzyme activity was expressed as nanograms per min/mg tissue. Treatment with delta 4 A increased estrogen concentration at midgestation 3-fold to levels comparable to those measured near term. Although fetal adrenal weight was greater at term than at midgestation (p less than 0.05), weight was not increased by delta 4 A treatment. The specific activity (mean +/- SE) of fetal adrenal 17 alpha-OHase at midgestation (181 +/- 29) was increased (P less than 0.05) 3-fold by treatment with delta 4 A to levels (591 +/- 105) comparable to those in adrenal microsomes prepared from untreated animals near term (816 +/- 130). Enzyme activity in adrenals of MER-25-treated baboons was 40%, but not significantly lower than that in term controls.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2029384872 created "2016-06-24" @default.
• W2029384872 creator A5057078720 @default.
• W2029384872 creator A5060010329 @default.
• W2029384872 date "1991-05-01" @default.
• W2029384872 modified "2023-09-25" @default.
• W2029384872 title "Activation of the Baboon Fetal Pituitary-Adrenocortical Axis at Midgestation by Estrogen: Adrenal Δ5-3β-Hydroxysteroid Dehydrogenase and 17α-Hydroxylase-17,20-Lyase Activity*" @default.
• W2029384872 cites W1546029719 @default.
• W2029384872 cites W1973124057 @default.
• W2029384872 cites W1974818475 @default.
• W2029384872 cites W1977244459 @default.
• W2029384872 cites W1981092683 @default.
• W2029384872 cites W1987860847 @default.
• W2029384872 cites W1988701791 @default.
• W2029384872 cites W1992743900 @default.
• W2029384872 cites W1994188236 @default.
• W2029384872 cites W1996918135 @default.
• W2029384872 cites W2000989152 @default.
• W2029384872 cites W2012688990 @default.
• W2029384872 cites W2022815472 @default.
• W2029384872 cites W2024419018 @default.
• W2029384872 cites W2028704990 @default.
• W2029384872 cites W2033764428 @default.
• W2029384872 cites W2041472359 @default.
• W2029384872 cites W2041760775 @default.
• W2029384872 cites W2044311625 @default.
• W2029384872 cites W2075251983 @default.
• W2029384872 cites W2076425945 @default.
• W2029384872 cites W2077323442 @default.
• W2029384872 cites W2082039887 @default.
• W2029384872 cites W2082288584 @default.
• W2029384872 cites W2082347294 @default.
• W2029384872 cites W2082567965 @default.
• W2029384872 cites W2083372031 @default.
• W2029384872 cites W2114130634 @default.
• W2029384872 cites W2119220091 @default.
• W2029384872 cites W2121674861 @default.
• W2029384872 cites W2146871543 @default.
• W2029384872 cites W2147452643 @default.
• W2029384872 cites W2148186477 @default.
• W2029384872 cites W2150062469 @default.
• W2029384872 cites W2169948668 @default.
• W2029384872 doi "https://doi.org/10.1210/endo-128-5-2395" @default.
• W2029384872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2019257" @default.
• W2029384872 hasPublicationYear "1991" @default.
• W2029384872 type Work @default.
• W2029384872 sameAs 2029384872 @default.
• W2029384872 citedByCount "19" @default.
• W2029384872 crossrefType "journal-article" @default.
• W2029384872 hasAuthorship W2029384872A5057078720 @default.
• W2029384872 hasAuthorship W2029384872A5060010329 @default.
• W2029384872 hasConcept C126322002 @default.
• W2029384872 hasConcept C134018914 @default.
• W2029384872 hasConcept C172680121 @default.
• W2029384872 hasConcept C181199279 @default.
• W2029384872 hasConcept C2776683971 @default.
• W2029384872 hasConcept C2777164284 @default.
• W2029384872 hasConcept C2777911890 @default.
• W2029384872 hasConcept C2779234561 @default.
• W2029384872 hasConcept C2779594886 @default.
• W2029384872 hasConcept C2780193516 @default.
• W2029384872 hasConcept C2780902042 @default.
• W2029384872 hasConcept C54355233 @default.
• W2029384872 hasConcept C55493867 @default.
• W2029384872 hasConcept C71315377 @default.
• W2029384872 hasConcept C71924100 @default.
• W2029384872 hasConcept C86803240 @default.
• W2029384872 hasConcept C87644729 @default.
• W2029384872 hasConceptScore W2029384872C126322002 @default.
• W2029384872 hasConceptScore W2029384872C134018914 @default.
• W2029384872 hasConceptScore W2029384872C172680121 @default.
• W2029384872 hasConceptScore W2029384872C181199279 @default.
• W2029384872 hasConceptScore W2029384872C2776683971 @default.
• W2029384872 hasConceptScore W2029384872C2777164284 @default.
• W2029384872 hasConceptScore W2029384872C2777911890 @default.
• W2029384872 hasConceptScore W2029384872C2779234561 @default.
• W2029384872 hasConceptScore W2029384872C2779594886 @default.
• W2029384872 hasConceptScore W2029384872C2780193516 @default.
• W2029384872 hasConceptScore W2029384872C2780902042 @default.
• W2029384872 hasConceptScore W2029384872C54355233 @default.
• W2029384872 hasConceptScore W2029384872C55493867 @default.
• W2029384872 hasConceptScore W2029384872C71315377 @default.
• W2029384872 hasConceptScore W2029384872C71924100 @default.
• W2029384872 hasConceptScore W2029384872C86803240 @default.
• W2029384872 hasConceptScore W2029384872C87644729 @default.
• W2029384872 hasLocation W20293848721 @default.
• W2029384872 hasLocation W20293848722 @default.
• W2029384872 hasOpenAccess W2029384872 @default.
• W2029384872 hasPrimaryLocation W20293848721 @default.
• W2029384872 hasRelatedWork W1972664531 @default.
• W2029384872 hasRelatedWork W1987914672 @default.
• W2029384872 hasRelatedWork W2036265737 @default.
• W2029384872 hasRelatedWork W2050826448 @default.
• W2029384872 hasRelatedWork W2065824050 @default.
• W2029384872 hasRelatedWork W2080498417 @default.
• W2029384872 hasRelatedWork W2092034319 @default.
• W2029384872 hasRelatedWork W2141847421 @default.
• W2029384872 hasRelatedWork W2150541284 @default.
• W2029384872 hasRelatedWork W2321140563 @default.
• W2029384872 isParatext "false" @default.

• next