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- W2029385890 abstract "Diseases of the liver afflict more than 10% of the world population; however, our strategies for diagnosis, staging, and treatment of liver diseases remain limited. Protein signatures in liver tissue samples may be useful tools in the development of diagnostics. In addition, many of the proteins in plasma are synthesized in the liver; the abundance and structures of many of these proteins change in response to liver diseases, as well as in response to inflammation and disease processes in other organs. Characterization of the liver proteome has become an essential step towards improvements in care for patients with liver diseases and will serve as the basis for current and future research. The number of liver proteins is very large and characterization of these proteins is complicated both by post-translational modifications and by splicing variants of the gene products. Other key challenges include localization of proteins in the cell and protein‐protein interactions. Proteomics offers hope for tackling this complexity and heralds significant advances in patient care." @default.
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- W2029385890 date "2005-07-01" @default.
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- W2029385890 title "Proteomics in the study of liver pathology" @default.
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