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• W202938641 abstract "This chapter discusses two major cardiac energetics, compartmentation of creatine kinase (CK) and oxidative phosphorylation. The creatine kinase (CK) isoenzymes function, in vivo , to intracellular structures such as mitochondria, myofibrils, and cellular membranes. They operate at equilibrium in the cytoplasm as part of the intracellular creatine phosphate (PCr) pathway, or “phosphocreatine circuit” for energy channeling. The chapter also focuses on introduction to the CK system. Compartmentalization of CK enzymes are involved in cardiac energy metabolism. Very recent experimental work with membrane permeabilized cells has shown that besides an energy transport function the CK system may also regulate cellular respiration as a result of the retarded or restricted diffusion of adenosine diphosphate (ADP) inside the cells. These data are outlined and explained in this chapter. A hypothesis based on local oscillating changes of ADP and creatine concentrations and a feedback signal between contraction and respiration in heart and skeletal muscle is also introduced." @default.
• W202938641 created "2016-06-24" @default.
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• W202938641 date "1996-01-01" @default.
• W202938641 modified "2023-09-27" @default.
• W202938641 title "Cardiac Energetics" @default.
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• W202938641 doi "https://doi.org/10.1016/b978-012186340-1/50008-4" @default.
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