FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029389633> ?p ?o ?g. }

• W2029389633 endingPage "1500" @default.
• W2029389633 startingPage "1491" @default.
• W2029389633 abstract "1 The roles of chymase in acute allergic responses are not clear, despite the relative abundance of this serine proteinase in the secretory granules of human mast cells. We have isolated chymase to high purity from human skin tissue by heparin-agarose affinity chromatography and Sephacryl S-200 gel filtration procedures, and have investigated the ability of human mast cell chymase to stimulate cell accumulation following injection into laboratory animals. 2 Injection of chymase provoked marked neutrophilia and eosinophilia in the skin of Dunkin Hartley guinea-pigs. Compared with saline injected control animals, there were some 60 fold more neutrophils and 12 fold more eosinophils present at the injection site. 3 Following injection of chymase into the peritoneum of BALB/c mice, there were up to 700 fold more neutrophils, 21 fold more eosinophils, 19 fold more lymphocytes and 7 fold more macrophages recovered than from saline injected controls at 16 h. Doses of chymase as low as 5 ng (1.7×10−13 mole) stimulated an inflammatory infiltrate, and significant neutrophilia was elicited within 3 h. 4 The chymase induced cell accumulation in both the guinea-pig and mouse models was dependent on an intact catalytic site, being reduced by co-injection of proteinase inhibitors or heat inactivation of the enzyme. 5 Co-injection of histamine or heparin significantly reduced the chymase induced neutrophil accumulation, whereas neither histamine nor heparin by themselves had any effect on the accumulation of nucleated cells. No synergistic or antagonist interactions between chymase and tryptase were observed when these two major mast cell proteinases were co-injected into the mouse peritoneum. 6 Our findings suggest that chymase may provide an potent stimulus for inflammatory cell recruitment following mast cell activation. British Journal of Pharmacology (1998) 125, 1491–1500; doi:10.1038/sj.bjp.0702223" @default.
• W2029389633 created "2016-06-24" @default.
• W2029389633 creator A5014684811 @default.
• W2029389633 creator A5073510977 @default.
• W2029389633 date "1998-12-01" @default.
• W2029389633 modified "2023-10-18" @default.
• W2029389633 title "Human mast cell chymase induces the accumulation of neutrophils, eosinophils and other inflammatory cells<i>in vivo</i>" @default.
• W2029389633 cites W1494869776 @default.
• W2029389633 cites W1501230571 @default.
• W2029389633 cites W1504566925 @default.
• W2029389633 cites W1512161015 @default.
• W2029389633 cites W1521804991 @default.
• W2029389633 cites W1543429526 @default.
• W2029389633 cites W1549183351 @default.
• W2029389633 cites W1568215152 @default.
• W2029389633 cites W1569539217 @default.
• W2029389633 cites W1577742891 @default.
• W2029389633 cites W1609709339 @default.
• W2029389633 cites W1680126513 @default.
• W2029389633 cites W1907210710 @default.
• W2029389633 cites W1947012228 @default.
• W2029389633 cites W1969412058 @default.
• W2029389633 cites W1971339219 @default.
• W2029389633 cites W1973485202 @default.
• W2029389633 cites W1979585315 @default.
• W2029389633 cites W1984733241 @default.
• W2029389633 cites W1990383981 @default.
• W2029389633 cites W1992995831 @default.
• W2029389633 cites W1996357329 @default.
• W2029389633 cites W2002715692 @default.
• W2029389633 cites W2015647584 @default.
• W2029389633 cites W2017752454 @default.
• W2029389633 cites W2029967744 @default.
• W2029389633 cites W2037583192 @default.
• W2029389633 cites W2043526402 @default.
• W2029389633 cites W2057203934 @default.
• W2029389633 cites W2065719831 @default.
• W2029389633 cites W2071833026 @default.
• W2029389633 cites W2079961511 @default.
• W2029389633 cites W2080502516 @default.
• W2029389633 cites W2081592351 @default.
• W2029389633 cites W2081753893 @default.
• W2029389633 cites W2082218171 @default.
• W2029389633 cites W2085415533 @default.
• W2029389633 cites W2091402529 @default.
• W2029389633 cites W2099613681 @default.
• W2029389633 cites W2115554448 @default.
• W2029389633 cites W2129479596 @default.
• W2029389633 cites W2137753146 @default.
• W2029389633 cites W2139934545 @default.
• W2029389633 cites W2143658570 @default.
• W2029389633 cites W2144762997 @default.
• W2029389633 cites W2150403127 @default.
• W2029389633 cites W2155326631 @default.
• W2029389633 cites W2156627022 @default.
• W2029389633 cites W2181624522 @default.
• W2029389633 cites W2339475902 @default.
• W2029389633 cites W2417244835 @default.
• W2029389633 cites W244106516 @default.
• W2029389633 cites W2467127600 @default.
• W2029389633 cites W4293247451 @default.
• W2029389633 cites W4313333821 @default.
• W2029389633 doi "https://doi.org/10.1038/sj.bjp.0702223" @default.
• W2029389633 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1565734" @default.
• W2029389633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9884078" @default.
• W2029389633 hasPublicationYear "1998" @default.
• W2029389633 type Work @default.
• W2029389633 sameAs 2029389633 @default.
• W2029389633 citedByCount "153" @default.
• W2029389633 countsByYear W20293896332012 @default.
• W2029389633 countsByYear W20293896332013 @default.
• W2029389633 countsByYear W20293896332014 @default.
• W2029389633 countsByYear W20293896332015 @default.
• W2029389633 countsByYear W20293896332016 @default.
• W2029389633 countsByYear W20293896332017 @default.
• W2029389633 countsByYear W20293896332018 @default.
• W2029389633 countsByYear W20293896332019 @default.
• W2029389633 countsByYear W20293896332020 @default.
• W2029389633 countsByYear W20293896332021 @default.
• W2029389633 countsByYear W20293896332022 @default.
• W2029389633 countsByYear W20293896332023 @default.
• W2029389633 crossrefType "journal-article" @default.
• W2029389633 hasAuthorship W2029389633A5014684811 @default.
• W2029389633 hasAuthorship W2029389633A5073510977 @default.
• W2029389633 hasBestOaLocation W20293896332 @default.
• W2029389633 hasConcept C1122143 @default.
• W2029389633 hasConcept C126322002 @default.
• W2029389633 hasConcept C134018914 @default.
• W2029389633 hasConcept C181199279 @default.
• W2029389633 hasConcept C185592680 @default.
• W2029389633 hasConcept C203014093 @default.
• W2029389633 hasConcept C2776042228 @default.
• W2029389633 hasConcept C2777037409 @default.
• W2029389633 hasConcept C2777132095 @default.
• W2029389633 hasConcept C2777802486 @default.
• W2029389633 hasConcept C2779726688 @default.
• W2029389633 hasConcept C2780614898 @default.
• W2029389633 hasConcept C2781044401 @default.

• next