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• W2029389945 abstract "Saliva secretion was elicited from the isolated preparations by isoproterenol and phenyl-ephrine, at concentrations from 10−8 to 10−5 M. The volumes of saliva secreted during a 60-min period, the rates of flow and the electrolyte composition of saliva secreted in response to each secretagogue were similar to those in vivo. Replacement of perfusate Na+ inhibited the secretion of fluid induced by isoproterenol (75 per cent) and by phenylephrine (99 per cent). It also reduced the Na+ and K+ concentrations of saliva elicited by the two secretagogues and inhibited isoproterenol-induced protein secretion (81 per cent). Omission of Ca2+ from the perfusate also inhibited fluid secretion (isoproterenol-stimulated, 84 per cent; phenylephrine-stimulated, 99 per cent) and isoproterenol-induced protein secretion (69 per cent). The absence of the divalent cation in the perfusate resulted in increased Na+ and decreased K+ concentrations in isoproterenol-stimulated saliva and in reduced K+ concentrations in phenylephrine-stimulated saliva. Administration of 10−5M phentolamine did not modify the volume of saliva secreted in response to isoproterenol, but reduced the response to phenylephrine by 90 per cent. The antagonist caused some reduction in the Na+ and K+ concentrations of isoproterenol-stimulated saliva, but did not modify those of phenylephrine-evoked secretion. Little recovery in fluid secretion was observed when the isolated gland was perfused with complete perfusate in the presence of phenylephrine after perfusion with Na+- or Ca2+-free solutions. Thus perfused rat submandibular glands are fully functional preparations, which respond to sympathomimetic agents of the α and β types. Both external Na+ and Ca2+ are required for fluid secretion with either type of stimulus, a finding which suggests that a similar ionic mechanism, involving an influx or mobilization of Ca2+ and Na+, is activated for the secretion of saliva when either α or β adrenergic receptors are stimulated by appropriate agonists." @default.
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• W2029389945 date "1983-01-01" @default.
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• W2029389945 title "Salivary secretion induced from isolated, perfused rat submandibular glands by sympathomimetic agents" @default.
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• W2029389945 doi "https://doi.org/10.1016/0003-9969(83)90165-6" @default.
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