Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029398997> ?p ?o ?g. }
- W2029398997 endingPage "36" @default.
- W2029398997 startingPage "29" @default.
- W2029398997 abstract "Neuropeptide S (NPS) is a 20-aminoacid peptide that selectively activates a G-protein coupled receptor named NPSR. Preclinical studies have shown that NPSR activation promotes anxiolysis, hyperlocomotion, arousal and weakfullness. Previous findings suggest that dopamine neurotransmission plays a role in the actions of NPS. Based on the close relationship between dopamine and Parkinson disease (PD) and on the evidence that NPSR are expressed on brain dopaminergic nuclei, the present study investigated the effects of NPS in motor deficits induced by intracerebroventricular (icv) administration of the dopaminergic neurotoxin 6-OHDA in the mouse rotarod test. 6-OHDA injection evoked motor deficits and significantly reduced tyrosine hidroxylase (TH)-positive cells in the substantia nigra (SN) and ventral tegmental area. However, a positive correlation was found only between the motor performance of 6-OHDA-injected mice and the number of TH-positive cells in SN. The systemic administration of l-DOPA + benserazide (25 + 6.25 mg/kg) counteracted 6-OHDA-induced motor deficits in mice. Similar to l-DOPA, the icv injection of NPS (0.1 and 1 nmol) reversed motor deficits evoked by 6-OHDA. In conclusion, NPS attenuated 6-OHDA-induced motor impairments in mice assessed in the rota-rod test. We discussed the beneficial actions of NPS based on a putative facilitation of dopaminergic neurotransmission in the brain. Finally, these findings candidate NPSR agonists as a potential innovative treatment for PD." @default.
- W2029398997 created "2016-06-24" @default.
- W2029398997 creator A5024567098 @default.
- W2029398997 creator A5028341235 @default.
- W2029398997 creator A5032888963 @default.
- W2029398997 creator A5043696468 @default.
- W2029398997 creator A5046366072 @default.
- W2029398997 creator A5061719307 @default.
- W2029398997 creator A5075899873 @default.
- W2029398997 creator A5083584375 @default.
- W2029398997 creator A5087303934 @default.
- W2029398997 date "2014-06-01" @default.
- W2029398997 modified "2023-10-18" @default.
- W2029398997 title "Neuropeptide S counteracts 6-OHDA-induced motor deficits in mice" @default.
- W2029398997 cites W1554259536 @default.
- W2029398997 cites W1665550861 @default.
- W2029398997 cites W1786092055 @default.
- W2029398997 cites W1983664046 @default.
- W2029398997 cites W1985378942 @default.
- W2029398997 cites W1994044142 @default.
- W2029398997 cites W1996601610 @default.
- W2029398997 cites W2003943670 @default.
- W2029398997 cites W2006696253 @default.
- W2029398997 cites W2008560062 @default.
- W2029398997 cites W2011664501 @default.
- W2029398997 cites W2013745847 @default.
- W2029398997 cites W2020763825 @default.
- W2029398997 cites W2021534443 @default.
- W2029398997 cites W2025312022 @default.
- W2029398997 cites W2026030437 @default.
- W2029398997 cites W2028980996 @default.
- W2029398997 cites W2037457092 @default.
- W2029398997 cites W2038716909 @default.
- W2029398997 cites W2052450120 @default.
- W2029398997 cites W2057494446 @default.
- W2029398997 cites W2061535870 @default.
- W2029398997 cites W2062605045 @default.
- W2029398997 cites W2062938118 @default.
- W2029398997 cites W2070991943 @default.
- W2029398997 cites W2080485913 @default.
- W2029398997 cites W2091999535 @default.
- W2029398997 cites W2095073691 @default.
- W2029398997 cites W2111372308 @default.
- W2029398997 cites W2120890476 @default.
- W2029398997 cites W2121361277 @default.
- W2029398997 cites W2129643184 @default.
- W2029398997 cites W2132815656 @default.
- W2029398997 cites W2138522158 @default.
- W2029398997 cites W2141035651 @default.
- W2029398997 cites W2146545384 @default.
- W2029398997 cites W2149408200 @default.
- W2029398997 cites W2158197796 @default.
- W2029398997 cites W2169890833 @default.
- W2029398997 doi "https://doi.org/10.1016/j.bbr.2014.03.002" @default.
- W2029398997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24613977" @default.
- W2029398997 hasPublicationYear "2014" @default.
- W2029398997 type Work @default.
- W2029398997 sameAs 2029398997 @default.
- W2029398997 citedByCount "18" @default.
- W2029398997 countsByYear W20293989972015 @default.
- W2029398997 countsByYear W20293989972016 @default.
- W2029398997 countsByYear W20293989972018 @default.
- W2029398997 countsByYear W20293989972019 @default.
- W2029398997 countsByYear W20293989972020 @default.
- W2029398997 countsByYear W20293989972021 @default.
- W2029398997 countsByYear W20293989972022 @default.
- W2029398997 crossrefType "journal-article" @default.
- W2029398997 hasAuthorship W2029398997A5024567098 @default.
- W2029398997 hasAuthorship W2029398997A5028341235 @default.
- W2029398997 hasAuthorship W2029398997A5032888963 @default.
- W2029398997 hasAuthorship W2029398997A5043696468 @default.
- W2029398997 hasAuthorship W2029398997A5046366072 @default.
- W2029398997 hasAuthorship W2029398997A5061719307 @default.
- W2029398997 hasAuthorship W2029398997A5075899873 @default.
- W2029398997 hasAuthorship W2029398997A5083584375 @default.
- W2029398997 hasAuthorship W2029398997A5087303934 @default.
- W2029398997 hasConcept C126322002 @default.
- W2029398997 hasConcept C134018914 @default.
- W2029398997 hasConcept C137183658 @default.
- W2029398997 hasConcept C15744967 @default.
- W2029398997 hasConcept C169760540 @default.
- W2029398997 hasConcept C185592680 @default.
- W2029398997 hasConcept C2777288102 @default.
- W2029398997 hasConcept C2779026782 @default.
- W2029398997 hasConcept C2779134260 @default.
- W2029398997 hasConcept C2779734285 @default.
- W2029398997 hasConcept C2780304432 @default.
- W2029398997 hasConcept C2780938664 @default.
- W2029398997 hasConcept C2780948874 @default.
- W2029398997 hasConcept C513476851 @default.
- W2029398997 hasConcept C71924100 @default.
- W2029398997 hasConceptScore W2029398997C126322002 @default.
- W2029398997 hasConceptScore W2029398997C134018914 @default.
- W2029398997 hasConceptScore W2029398997C137183658 @default.
- W2029398997 hasConceptScore W2029398997C15744967 @default.
- W2029398997 hasConceptScore W2029398997C169760540 @default.
- W2029398997 hasConceptScore W2029398997C185592680 @default.
- W2029398997 hasConceptScore W2029398997C2777288102 @default.