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- W2029406961 abstract "CD147, also named basigin (Bsg) or extracellular matrix (ECM) metalloproteinase inducer (EMMPRIN), is a highly glycosylated protein first identified as a tumor cell surface molecule. In cancer, it is well established that CD147 promotes metastasis by stimulating the production of MMPs. Recent studies have also suggested that it may be associated with tumor growth and angiogenesis. Interestingly, CD147 is expressed in germ cells of different development stages in the testis and its knockout mice are infertile, indicating an essential role of CD147 in spermatogenesis. While the detailed involvement of CD147 in spermatogenesis remains elusive, our recent findings have revealed a dual role of CD147 in germ cell development. On the one hand, it regulates the migration of spermatogonia and spermatocytes via the induction of MMP-2 production; on the other hand, it specifically regulates the survival/apoptosis of spermatocytes but not spermatogonia through a p53-independent pathway. In this review, we aim to provide an overview on the functions of CD147, comparing its roles in cancer and the testis, thereby providing new insights into the regulatory mechanisms underlying the process of spermatogenesis." @default.
- W2029406961 created "2016-06-24" @default.
- W2029406961 creator A5033985160 @default.
- W2029406961 creator A5048153239 @default.
- W2029406961 creator A5053170113 @default.
- W2029406961 creator A5059526453 @default.
- W2029406961 date "2012-10-01" @default.
- W2029406961 modified "2023-10-11" @default.
- W2029406961 title "New insights into germ cell migration and survival/apoptosis in spermatogenesis" @default.
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- W2029406961 doi "https://doi.org/10.4161/spmg.22014" @default.
- W2029406961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3521748" @default.
- W2029406961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23248767" @default.
- W2029406961 hasPublicationYear "2012" @default.
- W2029406961 type Work @default.